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Specifications
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Appearance |
Colorless or light yellow liquid without suspension |
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Active sec-Butyllithium content |
1.3 mol in hexane |
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Activity |
98% min |
Transport Information
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Parameter |
Specification |
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UN Number |
3394 |
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Class |
4 |
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Packing Group |
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H.S. Code |
2931900090 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Tightly closed. Store in a closed, dry, ventilated place |
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Condition to Avoid |
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Package |
Manufacturing Information
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Parameter |
Specification |
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Capacity |
1,500MT/year |
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Frequency |
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Main Export Countries |
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Capacity/Batch |
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Experience |
Production since 2001 |
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Stock |
Applications of sec-Butyllithium丨CAS 598-30-1
1. Strong Base and Nucleophile in Organic Synthesis
Widely used as a strong, non-nucleophilic base for deprotonation reactions.
Key reagent for metalation reactions, enabling lithiation of aromatic, heteroaromatic, and aliphatic compounds.
Facilitates formation of carbon-carbon bonds in complex molecule synthesis.
2. Synthesis of Pharmaceuticals and Fine Chemicals
Used in the preparation of intermediates for pharmaceutical drugs, agrochemicals, and specialty chemicals.
Enables precise functional group transformations, including alkylations, additions, and substitutions.
3. Polymer Chemistry
Acts as an initiator or catalyst in anionic polymerization processes to create polymers with controlled architectures.
4. Organometallic Chemistry
Utilized in the preparation of other organometallic reagents through transmetalation reactions.
Used in the synthesis of lithium-containing organometallic compounds.
Benefits
✅ High Reactivity
Extremely strong base and nucleophile, enabling transformations not possible with weaker reagents.
✅ Selectivity
sec-Butyllithium allows for selective deprotonation and lithiation due to steric and electronic effects.
✅ Versatility
Applicable in a wide range of synthetic methodologies, including cross-coupling, rearrangements, and cyclizations.
Summary
sec-Butyllithium丨CAS 598-30-1 is a highly reactive organolithium reagent widely used as a strong base and nucleophile in organic synthesis. Its ability to perform selective lithiation and deprotonation reactions makes it indispensable in pharmaceutical synthesis, polymer chemistry, and organometallic research. Due to its extreme reactivity and pyrophoric nature, careful handling and specialized equipment are necessary.
