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Specifications
| Description | Off-white powder |
| NMR | Conforms |
| Purity (HPLC) | 98.00% min |
| Titration with NaOH | 96.00% min |
Applications
1. Suzuki–Miyaura Cross-Coupling Reactions
A widely used boronic acid building block for C–C bond formation.
Common in organic synthesis, especially for biaryl compounds in pharmaceuticals, agrochemicals, and materials science.
2. Pharmaceutical & Medicinal Chemistry
Intermediate in synthesizing molecules with antitumor, antiviral, or anti-inflammatory activities.
Carboxylic acid moiety enhances water solubility and potential for targeted drug design.
3. Functional Material Development
Useful in making boronic acid-functionalized polymers, MOFs, or biosensors.
The boronic group allows reversible binding with diols (e.g., in glucose sensing).
4. Bioconjugation and Surface Chemistry
Acts as a linker for covalent immobilization on sensor surfaces or for tagging biomolecules.
Benefits
✅ Dual Reactivity: Boronic acid for coupling + carboxylic acid for further derivatization
✅ Versatile Intermediate: Widely applicable in material science, medicinal chemistry, and polymer synthesis
✅ Good Solubility in Polar Solvents: Suitable for aqueous-phase reactions or biological applications
Conclusion
4-Carboxyphenylboronic acid (CAS 14047-29-1) is a valuable and versatile compound for both synthetic chemistry and biomolecular engineering. Its combination of boronic and carboxylic acid groups makes it ideal for applications ranging from Suzuki couplings to biosensor design and drug discovery.
