Tert-Butyl 4-iodopyrazole-1-carboxylate丨CAS 121669-70-3

tert-Butyl 4-iodopyrazole-1-carboxylate (CAS 121669-70-3) is a valuable heterocyclic intermediate frequently used in pharmaceutical and fine chemical synthesis. It serves as a key building block for the preparation of pyrazole-based drugs, agrochemicals, and biologically active compounds. The iodine substituent at the 4-position allows for diverse cross-coupling reactions such as Suzuki, Sonogashira, or Buchwald–Hartwig coupling, enabling efficient formation of C–C and C–N bonds. This compound is also utilized in medicinal chemistry to construct libraries of heterocyclic molecules with potential anti-inflammatory, antiviral, and anticancer properties.

The main benefits of tert-Butyl 4-iodopyrazole-1-carboxylate include its high reactivity and synthetic versatility. The tert-butyl carbamate (Boc) protecting group enhances stability and facilitates downstream functionalization under mild conditions. The iodine atom provides excellent leaving group ability, making it an ideal substrate for palladium-catalyzed reactions. Its compatibility with various reaction conditions and ease of purification make it an efficient intermediate for both small-scale research and large-scale industrial applications.