(S)-(+)-3-Hydroxytetrahydrofuran丨CAS 86087-23-2

(S)-(+)-3-Hydroxytetrahydrofuran (CAS 86087-23-2) is a chiral oxygen-containing heterocycle widely used as an intermediate in pharmaceutical, agrochemical, and fine chemical synthesis. Its enantiomerically pure form makes it particularly valuable in the preparation of chiral drug candidates, active pharmaceutical ingredients (APIs), and stereochemically defined intermediates. The hydroxyl group enables further functionalization through esterification, etherification, oxidation, or substitution reactions, allowing incorporation into more complex molecular frameworks. It is also used in the synthesis of nucleoside analogues, chiral auxiliaries, and ligands, as well as in structure–activity relationship studies where controlled stereochemistry is essential. In research settings, it serves as a model compound for studying chiral heterocycles and stereoselective transformations.

The benefits of (S)-(+)-3-hydroxytetrahydrofuran arise from its high enantiomeric purity, structural simplicity, and versatile reactivity. The defined (S)-configuration enables precise control of stereochemistry in downstream synthesis, which is critical for achieving desired biological activity and regulatory compliance in pharmaceuticals. The tetrahydrofuran ring provides chemical stability and favorable solubility in common organic solvents, while the hydroxyl functionality offers multiple pathways for selective derivatization. Its compatibility with standard synthetic conditions allows efficient, reproducible reactions and scalable processes. These properties make it a reliable and flexible chiral building block for complex molecule construction.