4-Bromo-3-fluorobenzaldehyde丨CAS 133059-43-5

1. Pharmaceutical Intermediates

Used in the synthesis of heterocyclic and aromatic pharmaceutical compounds.

Valuable for creating fluorinated and halogenated drug candidates, especially those targeting CNS, oncology, or inflammatory diseases.

The aldehyde group allows for further transformations such as:

Schiff base formation

Reductive amination

Condensation reactions

2. Agrochemical Intermediate

Acts as a building block for pesticides, herbicides, and fungicides, especially those requiring halogenated aromatic rings to enhance environmental stability and bioactivity.

3. Material Science

Used in the synthesis of fluorinated aromatic compounds for OLEDs, dyes, and organic semiconductors.

The bromo and fluoro substituents influence electronic properties, making it suitable for designing high-performance materials.

4. Chemical Synthesis

A versatile intermediate in:

Cross-coupling reactions (e.g., Suzuki, Heck, or Sonogashira couplings via the bromo group)

Nucleophilic substitutions

Oxidation or reduction to acids or alcohols

The dual halogen functionality offers selective reaction handles for stepwise functionalization.

✅ Dual Halogen Substitution

Bromine and fluorine substituents provide:

Synthetic versatility for site-selective reactions

Tuning of electron distribution in the aromatic system

✅ Reactive Aldehyde Group

Easily undergoes:

Condensations, hydrazone/thiosemicarbazone formations

Nucleophilic additions

Functional group interconversions

✅ Fluorinated Building Block

Enhances lipophilicity, metabolic stability, and receptor binding in pharmaceutical targets

Important for structure–activity relationship (SAR) studies

✅ Useful in Fragment-Based Design

Small molecular weight and functional diversity make it ideal for fragment-based drug discovery (FBDD).