Methyl 4-broMo-5-fluoro-2-hydroxy-benzoate丨CAS 1193162-25-2

Methyl 4-bromo-5-fluoro-2-hydroxybenzoate is a halogenated aromatic ester widely used as an intermediate in pharmaceutical, agrochemical, and fine chemical synthesis. Its hydroxy and ester functionalities allow for versatile chemical transformations, including esterification, amidation, nucleophilic substitution, and cross-coupling reactions. The bromine and fluorine substituents provide reactive sites for selective functionalization, making it a valuable building block for the synthesis of bioactive molecules, heterocyclic compounds, and medicinal chemistry analogs. It is particularly useful in the preparation of enzyme inhibitors, antiviral agents, and other therapeutic candidates, as well as in research for structure–activity relationship (SAR) studies and the development of novel halogenated derivatives with optimized biological activity.

The benefits of methyl 4-bromo-5-fluoro-2-hydroxybenzoate stem from its chemical stability, reactivity, and structural versatility. The hydroxy group allows for selective derivatization, while the ester functionality provides an accessible site for further transformations or deprotection under mild conditions. The bromine and fluorine substituents enhance reactivity in cross-coupling reactions, improve electronic and lipophilic properties, and can modulate pharmacokinetic characteristics in downstream molecules. Its high purity and well-defined structure ensure reproducible reactions and high yields, making it suitable for both laboratory-scale research and industrial synthesis of complex molecules.