Binol丨CAS 18531-99-2

Binol (1,1'-Bi-2-naphthol, CAS 18531-99-2) is a versatile chiral diol widely used in asymmetric synthesis, catalysis, and materials science. In organic chemistry, it serves as a key ligand for metal-catalyzed asymmetric reactions, including enantioselective reductions, additions, and cross-coupling reactions, enabling the production of chiral molecules with high optical purity. Binol is also used to prepare chiral phosphoric acids, BINOL-derived catalysts, and other chiral auxiliaries for stereoselective transformations. Beyond catalysis, it finds applications in the synthesis of optically active ligands for coordination chemistry, as a precursor for functional materials, and in the development of nonlinear optical compounds due to its rigid, planar, and conjugated structure. Its chirality and structural rigidity make it highly valuable in pharmaceutical synthesis, agrochemical development, and fine chemical research.

The benefits of Binol arise from its high optical purity, rigid chiral structure, and versatility as a ligand or building block. Its two naphthol units provide strong binding to metal centers, enabling precise control over stereochemistry in asymmetric catalysis. Binol's chemical stability and solubility in organic solvents facilitate its use under various reaction conditions, including high temperature and strong acids or bases. Its modular structure allows derivatization to produce phosphoric acids, sulfonamides, and other functional ligands for tailored catalytic performance. These characteristics enable efficient, high-yielding, and highly enantioselective reactions, making Binol a preferred chiral auxiliary in academic research and industrial synthesis of optically active compounds.