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Specifications
| Appearance | White or almost white crystalline powder |
| Assay | 98.0% to 100.5% |
| Optical rotation | -0.100 to +0.100 |
| Total impurity | Max 2.0% |
| Each impurity | Max 0.5% |
| Loss on drying | Max 0.5% |
| Sulphated ash | Max 0.1% |
| Melting Point | 148–153 °C |
Applications
Bifonazole is primarily used as a topical antifungal agent in pharmaceutical and healthcare products. It is incorporated into creams, lotions, and ointments for the treatment of dermatophytic infections such as athlete's foot, ringworm, and jock itch, as well as candidal and yeast-related skin conditions. In research, Bifonazole is employed to study antifungal mechanisms, azole resistance, and the efficacy of new formulations or combination therapies. It is also used as a reference compound in analytical laboratories for quality control and assay development in dermatological and antifungal product testing.
Benefits
Bifonazole offers several advantages in therapeutic and research contexts. Its broad-spectrum antifungal activity effectively inhibits the growth of dermatophytes, yeasts, and other fungal pathogens by targeting ergosterol synthesis in fungal cell membranes. The compound demonstrates strong topical efficacy with minimal systemic absorption, reducing the risk of side effects. Its chemical stability and compatibility with various excipients allow formulation into creams, gels, and sprays, providing convenient and reliable application. Additionally, Bifonazole serves as a useful standard in research for studying antifungal pharmacodynamics and the development of new antifungal agents.
Conclusion
Bifonazole is a widely used topical antifungal agent with applications in dermatology, pharmaceutical research, and analytical testing. Its broad-spectrum activity, topical efficacy, and formulation versatility make it valuable for treating fungal skin infections and supporting antifungal research. Overall, Bifonazole contributes to effective fungal infection management and the advancement of antifungal therapeutic development.
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