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Specifications
| Grade | BP2002 |
| Appearance | White or creamy white crystals or powder |
| Assay (dried basis) | 99.0%–101.0% |
| Solubility | Freely soluble in water, sparingly soluble in ethanol (96%) |
| Identification A | The IR spectrum of the sample corresponds to the IR spectrum of the RS |
| Identification B | Is the first identification of aromatic amines |
| Identification C | Test for sodium |
| Melting Range | 197°C–200°C |
| Clarity of Solution | Clear |
| Color of Solution | Not more than Reference solution Y |
| pH | 10.0–11.0 |
| Related Substances – Total Impurities | 0.5% max |
| Loss on Drying | 2.0% max |
Applications
Sulfamethazine sodium salt is a water-soluble sulfonamide antibiotic widely used in veterinary medicine, animal husbandry, and pharmaceutical research. It is primarily applied to prevent and treat bacterial infections in livestock and poultry, particularly those caused by Gram-positive and Gram-negative bacteria. Its rapid solubility in water makes it suitable for oral administration via drinking water or feed, enabling efficient dosing and uniform distribution in large-scale animal populations. In pharmaceutical research, sulfamethazine sodium salt serves as a reference compound for studying sulfonamide mechanisms, drug interactions, and resistance patterns. It is also used in combination with other antibiotics to enhance antimicrobial spectrum or efficacy, and in microbiological studies for selective inhibition of bacterial strains in culture systems. Additionally, it can be incorporated into formulations designed for controlled release, allowing extended therapeutic effects while minimizing frequent dosing.
Benefits
The benefits of sulfamethazine sodium salt stem from its high solubility, stability, and broad antimicrobial activity. Its water solubility allows for flexible administration in liquid formulations and ensures rapid absorption, resulting in effective systemic distribution. The compound exhibits strong inhibitory activity against a variety of bacterial pathogens by interfering with folic acid synthesis, a key process for bacterial growth and replication. Its sodium salt form enhances chemical stability and shelf-life, reducing degradation during storage and handling. The compound is compatible with other pharmaceutical excipients and can be incorporated into combination therapies or veterinary formulations. These properties make it highly efficient in preventing bacterial infections, improving animal health, and supporting optimized dosing strategies in livestock management.
Conclusion
Sulfamethazine sodium salt is a highly versatile sulfonamide antibiotic used in veterinary medicine, pharmaceutical research, and microbiological applications. Its water solubility, stability, and broad-spectrum antibacterial activity enable effective prevention and treatment of infections, while allowing flexible formulation options for oral administration and combination therapies. By supporting improved animal health, efficient drug delivery, and reliable research outcomes, sulfamethazine sodium salt remains an essential compound in veterinary pharmaceuticals and scientific studies related to antimicrobial therapy.
