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Specifications
| Grade | BP2017 |
| Appearance | A white or almost white, crystalline powder |
| Assay (C16H19N3O5S, calculated with anhydrous substance) | 95%–102% |
| Identification, Infrared Absorption spectrum | Infrared Absorption spectrum accord with the reference spectrum of Amoxicillin Trihydrate |
| Appearance of solution | The solutions are not more opalescent than reference suspension II |
| pH | 3.5–5.5 |
| Specific optical rotation | +290°–+315° |
| Related substances, Any impurity | 1.0% max |
| Dimethylaniline | 20 ppm max |
| Water | 11.5%–14.5% |
| Sulphated ash | 1.0% max |
Applications
Amoxicillin (CAS 26787-78-0) is a widely used β-lactam antibiotic with broad applications in human and veterinary medicine. It is effective against various Gram-positive and some Gram-negative bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and Helicobacter pylori-related gastric conditions. Amoxicillin is formulated in oral capsules, tablets, suspensions, and combinations with β-lactamase inhibitors for enhanced efficacy. Beyond clinical use, it is employed in pharmaceutical research as a standard antibiotic for testing bacterial susceptibility, developing combination therapies, and studying resistance mechanisms. Its well-characterized pharmacokinetics and safety profile also make it a reference compound in drug formulation and quality control studies.
Benefits
The benefits of Amoxicillin stem from its broad-spectrum antibacterial activity, favorable pharmacokinetics, and oral bioavailability. It is rapidly absorbed and widely distributed in the body, allowing effective treatment with convenient dosing regimens. Amoxicillin exhibits a strong safety profile with relatively low toxicity, making it suitable for pediatric and adult use. Its effectiveness against both Gram-positive and certain Gram-negative bacteria, along with stability in gastric acid, enables reliable therapy without the need for intravenous administration in most cases. Additionally, it can be combined with β-lactamase inhibitors to overcome resistant bacterial strains, extending its clinical utility. These features make Amoxicillin a trusted and widely prescribed antibiotic for diverse infectious diseases.
Conclusion
Amoxicillin is a highly effective and versatile β-lactam antibiotic used in the treatment of numerous bacterial infections in humans and animals. Its broad-spectrum activity, excellent oral bioavailability, and favorable safety profile make it a reliable therapeutic agent. By enabling efficient infection control and supporting research on antibacterial therapies, Amoxicillin continues to be a cornerstone in modern medicine and pharmaceutical development.
