Polycarbophil丨CAS 9003-97-8

Polycarbophil丨9003-97-8 is a synthetic, high molecular weight, crosslinked polyacrylic acid that has strong water-absorbing and mucoadhesive properties. It is best known for its bioadhesive gel-forming abilities, which make it useful in pharmaceutical and medical applications.

1. Pharmaceutical Industry
a. Drug Delivery Systems
● Polycarbophil丨9003-97-8 is widely used in controlled-release drug delivery systems.
● It swells upon hydration, forming a bioadhesive gel that adheres to mucosal surfaces (such as the gastrointestinal or vaginal mucosa), ensuring prolonged residence time and enhanced drug absorption.
b. Laxatives and GI Medications
● One of the most common applications is as the active ingredient in bulk-forming laxatives (e.g., in products like FiberCon).
● It absorbs water in the gastrointestinal tract, swelling to form a soft bulk that stimulates natural bowel movements and relieves constipation without harsh stimulation.
c. Topical and Mucosal Medications
● Used in topical gels and vaginal formulations for its ability to retain water, provide sustained release, and adhere to mucosal tissues, enhancing therapeutic efficacy.
2. Cosmetics and Personal Care Products
● Polycarbophil is utilized as a thickening, gelling, and stabilizing agent in various personal care products such as:
oMoisturizers
oEye creams
oFacial cleansers
oShaving gels
● Its non-irritating, non-sensitizing, and high water retention characteristics make it ideal for sensitive skin applications.
3. Ophthalmic and Nasal Preparations
● In eye drops, ocular gels, or nasal sprays, polycarbophil helps retain moisture on mucosal surfaces, reducing dryness and improving drug retention.
● Frequently found in formulations for dry eye syndrome and allergic rhinitis.
4. Oral and Dental Care
● Included in oral gels and mucoadhesive dental pastes to treat conditions like oral ulcers or periodontal disease, ensuring long-lasting contact with the affected area for targeted delivery.

1. Strong Bioadhesive Properties
● Adheres effectively to mucosal tissues, including oral, gastrointestinal, vaginal, and rectal areas, promoting localized and sustained drug release.
● Enhances therapeutic efficacy by maintaining contact time at the site of action.
2. High Water Absorption Capacity
● Absorbs many times its weight in water, forming a gel-like matrix that can function as a bulk-forming agent, a moisturizer, or a drug reservoir.
● Excellent for hydration support in formulations for skin, eyes, or mucosal tissue.
3. Non-Systemic Activity
● In products like laxatives, polycarbophil is not absorbed into the bloodstream, making it safe for long-term use with minimal risk of systemic side effects.
● Particularly suitable for populations that need gentle relief, such as elderly patients or those with chronic constipation.
4. Compatible and Non-Irritating
● Non-toxic, non-sensitizing, and biocompatible, making it suitable for use in topical, oral, ophthalmic, and mucosal formulations.
● Its safety profile has led to FDA approval in various drug and OTC products.
5. Environmentally Stable
● Polycarbophil is chemically stable over a wide pH range (especially in acidic to neutral conditions), enhancing the shelf life and performance of finished products.

Conclusion
Polycarbophil丨9003-97-8 is a versatile, safe, and highly functional polymer widely used in pharmaceuticals, cosmetics, and personal care industries. Its excellent water-absorbing and mucoadhesive properties make it especially valuable in controlled drug delivery, bulk-forming laxatives, and hydrating topical formulations. With a strong safety profile, regulatory acceptance, and multifunctional capabilities, polycarbophil continues to play an essential role in both healthcare and consumer product innovation.