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Calcium dobesilate丨CAS 20123-80-2
Calcium dobesilate (CAS 20123-80-2) is a vascular-protective agent and pharmaceutical compound used to improve microcirculation and capillary resistance. It is commonly applied in the treatment of chronic venous insufficiency, diabetic retinopathy, and other microvascular disorders by reducing capillary permeability and improving blood flow. The compound is also used in various formulations aimed at managing symptoms associated with vascular fragility and circulation impairment.
| Grade: | EP11.0 |
| Appearance: | White or almost white, hygroscopic powder. Very soluble in water, freely soluble in anhydrous ethanol, very slightly soluble in 2-propanol, practically insoluble in methylene chloride. |
| Assay: | 99.0%~101.0% (calculated on anhydrous basis, as C12H16CaO10S2·H2O) |
| Identification A: | Absorption maxima: at 221 nm and 301 nm. Specific absorbance at 301 nm: 174 to 181 |
| Identification B: | Should meet the requirement |
| Identification C: | Should meet the requirement |
| Appearance of solution: | Clear and colourless (when freshly prepared) |
| pH: | 4.5~6.0 |
| Impurity A: | Not more than the area of the principal peak in reference solution (a) (≤0.1%) |
| Unspecified impurities: | Each impurity ≤0.10% |
| Total impurities: | Not more than twice the area of the principal peak in reference solution (a) (≤0.2%) |
| Iron salt: | 10 ppm max |
| Water: | 4.0%~6.0% |
| Microbial limit: | Should meet the requirement |

