Hangzhou Leap Chem Co., Ltd. is one of the most professional manufacturers and suppliers of brimonidine tartrate丨cas 70359-46-5 in China. Welcome to wholesale custom made chemical products at competitive price from our factory. For more cheap products, contact us now.
Specifications
| Item | Specification |
| Appearance | White or slightly yellowish or slightly brownish powder |
| Identification | A. Specific optical rotation B. Infrared absorption spectrophotometry |
| Solubility | Soluble in water, practically insoluble in anhydrous ethanol and in toluene |
| Assay (On Dried Basis) | 99.0% ~ 101.0% |
| Specific Optical Rotation | +9.0° ~ +10.5° |
| Loss on Drying | 0.5% max |
| Sulfated Ash | 0.2% max |
| Heavy Metals | 20 ppm max |
| Residual Solvents | Bromobenzene 360 ppm max Acetone 3000 ppm max |
| Related Substances (Specified Impurities) | N-(imidazolidin-2-ylidene)quinoxalin-6-amine: 0.1% max 5-bromoquinoxalin-6-amine: 0.1% max Quinoxalin-6-amine: 0.1% max 1-(5-bromoquinoxalin-6-yl)thiourea: 0.1% max 2-(5-bromoquinoxalin-6-yl)guanidine: 0.1% max 5-bromo-N-(1H-imidazol-2-yl)quinoxalin-6-amine: 0.1% max 1-(2-aminoethyl)-3-(5-bromoquinoxalin-6-yl)urea: 0.1% max Unspecified Impurity: 0.1% max Total: 0.2% max |
Transport Information
|
Parameter |
Specification |
|
UN Number |
2811 |
|
Class |
6 |
|
Packing Group |
III |
|
H.S. Code |
2933290090302 |
|
Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
|
Storage |
Keep container tightly closed in a dry and well-ventilated place. |
|
Condition to Avoid |
|
|
Package |
Applications
Brimonidine tartrate (CAS 70359-46-5) is a selective α2-adrenergic receptor agonist primarily used in ophthalmology and medical research. Clinically, it is applied as an eye drop to reduce intraocular pressure in patients with glaucoma or ocular hypertension by decreasing aqueous humor production and increasing uveoscleral outflow. It is also used in combination therapies for enhanced control of intraocular pressure and may have applications in managing ocular redness due to its vasoconstrictive effects. In research, brimonidine tartrate is employed to study adrenergic receptor pharmacology, neuroprotective mechanisms, and potential therapeutic effects in ocular and systemic disorders.
Benefits
The benefits of brimonidine tartrate stem from its selectivity, efficacy, and safety profile. Its α2-adrenergic receptor specificity provides effective intraocular pressure reduction while minimizing systemic side effects associated with non-selective adrenergic agonists. The tartrate salt form enhances solubility, stability, and bioavailability, ensuring consistent dosing and formulation stability in ophthalmic solutions. Brimonidine tartrate also exhibits neuroprotective potential, which may provide additional benefits in preventing optic nerve damage. Its rapid onset and moderate duration of action allow flexible dosing regimens with predictable therapeutic outcomes.
Conclusion
In summary, brimonidine tartrate is an α2-adrenergic agonist used primarily to treat glaucoma and ocular hypertension. Its applications include intraocular pressure reduction, ocular vasoconstriction, and research on adrenergic pharmacology, while its benefits include receptor selectivity, improved solubility, formulation stability, and potential neuroprotective effects. As an effective and well-tolerated ophthalmic agent, brimonidine tartrate remains an important tool in glaucoma management and ocular therapeutics.
