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Specifications
| Appearance | White powder |
| HPLC | The retention time of the major peak of the sample solution corresponds to that of the standard solution as obtained in the assay |
| Solubility | Soluble in tetrahydrofuran, insoluble in water |
| Loss on drying | 0.5% max |
| Sulphated ash | 0.1% max |
| Heavy metals | 20 ppm max |
| Residual Solvents | Ethyl acetate: 0.5% max Methanol: 0.3% max Tetrahydrofuran: 0.072% max |
| Related Impurity | Impurity A: 0.3% max Impurity B: 0.1% max Impurity C: 0.15% max Impurity D: 0.2% max Unknown impurity: 0.1% max Total impurities: 0.5% max |
| Purity (HPLC) | 99% min |
| Assay | Not less than 98.0% and not more than 102.0% |
Applications
Adapalene (CAS 106685-40-9) is a third-generation synthetic retinoid widely used in dermatology. Its primary applications include the topical treatment of acne vulgaris, where it regulates skin cell turnover, prevents the formation of comedones, and reduces inflammation. It is also used in combination therapies for various acne-related conditions and is explored in research for other dermatological applications, including photoaging and hyperpigmentation treatment. Adapalene is incorporated into gels, creams, and lotions to ensure targeted delivery and efficacy on affected skin areas.
Benefits
The benefits of adapalene arise from its high stability, selective retinoid receptor activity, and favorable safety profile. Compared to earlier retinoids, it exhibits lower irritation and better skin tolerability while maintaining potent anti-acne activity. It effectively normalizes keratinization, reduces inflammation, and minimizes the risk of scarring, supporting long-term skin health. Its lipophilic nature allows for optimal skin penetration, enhancing therapeutic outcomes in topical formulations.
Conclusion
In conclusion, adapalene is a highly effective and well-tolerated retinoid for acne treatment and other dermatological applications. Its receptor selectivity, stability, and anti-inflammatory properties make it a preferred choice in topical therapies. By promoting skin normalization and preventing comedone formation, adapalene plays a crucial role in modern dermatological care and skincare formulations.
