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Specifications of Daptomycin丨CAS 103060-53-3
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Appearance: |
Yellow or pale yellow amorphous powder |
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Assay (on the anhydrous basis): |
93.0% min |
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Identification: |
HPLC, IR, UV |
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Specific rotation: |
+17° to +25° |
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PH: |
3.0 to 5.0 |
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Residue on ignition: |
4.0% max |
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Anhydro-daptomycin: |
3.5% max |
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β-Isomer: |
2.0% max |
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Lactone hydrolysis product: |
1.5% max |
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Impurity RS-2: |
0.5% max |
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Any other impurity: |
0.15% max |
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Total impurities: |
8.0% max |
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Residual organic solvents: |
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Ethanol: |
0.5% max |
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Isopropanol: |
0.5% max |
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Heavy metals: |
20 ppm max |
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Water: |
10.0% max |
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Bacterial Endotoxin: |
0.5 EU/mg max |
Transport Information of Daptomycin丨CAS 103060-53-3
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Parameter |
Specification |
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UN Number |
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Class |
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Packing Group |
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H.S. Code |
3004209099999 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Tightly closed. Dry. -20℃ |
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Condition to Avoid |
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Package |
Manufacturing Information of Daptomycin丨CAS 103060-53-3
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Parameter |
Specification |
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Capacity |
100kg/month |
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Frequency |
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Main Export Countries |
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Capacity/Batch |
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Experience |
Production since 2011 |
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Stock |
Overview
Daptomycin丨CAS 103060-53-3 is a naturally derived cyclic lipopeptide antibiotic produced by Streptomyces roseosporus. It has a unique mechanism of action and is known for its potent activity against Gram-positive bacteria, including multidrug-resistant strains.
Applications
1. Antibacterial Therapy
Primary Use: Treatment of serious Gram-positive bacterial infections, including:
Methicillin-resistant Staphylococcus aureus (MRSA)
Vancomycin-resistant Enterococcus faecium (VRE)
Streptococcus spp., including drug-resistant strains
FDA-approved Indications:
Complicated skin and skin structure infections (cSSSIs)
Staphylococcus aureus bacteremia, including right-sided infective endocarditis
2. Hospital and Critical Care Use
Employed in hospital settings for managing life-threatening infections, especially when other antibiotics fail due to resistance.
Used off-label for osteomyelitis, prosthetic joint infections, and central nervous system infections under physician supervision.
3. Research Applications
Utilized in antibiotic resistance studies, helping researchers understand how bacteria adapt to novel membrane-active agents.
Studied in pharmacodynamics and pharmacokinetics models to refine dosing regimens and improve therapeutic outcomes.
Benefits
1. Unique Mechanism of Action
Membrane-targeting antibiotic: Daptomycin丨CAS 103060-53-3 inserts into bacterial cell membranes in a calcium-dependent manner, causing membrane depolarization and cell death without lysis.
This mechanism differs from traditional antibiotics and helps reduce cross-resistance.
2. Potent Against Resistant Pathogens
Highly effective against multi-drug resistant Gram-positive organisms, including MRSA and VRE, which are increasingly common in hospital-acquired infections.
3. Bactericidal Activity
Exhibits rapid bactericidal effects, which is advantageous in acute infections and sepsis where fast bacterial clearance is critical.
4. Low Cross-Resistance
Since it targets the bacterial membrane, daptomycin often remains effective where β-lactams, glycopeptides, and other classes have failed.
5. Low Risk of Immunogenicity
As a non-glycopeptide, daptomycin has a lower likelihood of causing allergic reactions compared to penicillins or cephalosporins.
Conclusion
Daptomycin丨CAS 103060-53-3 is a powerful, membrane-active lipopeptide antibiotic used primarily for serious Gram-positive infections, including those caused by MRSA and VRE. Its novel mode of action, rapid bactericidal activity, and ability to bypass many forms of traditional antibiotic resistance make it an essential therapeutic agent in modern infectious disease management, particularly in critical care and hospital environments.
