Hangzhou Leap Chem Co., Ltd. is one of the most professional manufacturers and suppliers of dihydrostreptomycin sulfate丨cas 5490-27-7 in China. Welcome to wholesale bulk high quality chemical products at competitive price from our factory. If you have any enquiry about custom service, please feel free to email us.
Specifications
| Grade: | EP9.0 |
| Appearance: | White to off-white, hygroscopic powder |
| Assay(HPLC): | 95%~102% |
| PH: | 5.0–7.0 |
| Solubility: | Complies |
| Identification: | Complies |
| Appearance of solution: | |
| – Color: | 5 max |
| – Clarity: | II max |
| Specific optical rotation: | -83 ~ -91 deg |
| Impurity A: | 1.0% max |
| Impurity B: | 1.0% max |
| Impurity C: | 2.0% max |
| Any other impurity: | 1.0% max |
| Total impurities: | 5.0% max |
| Heavy metals: | 20 ppm max |
| Sodium metabisulfite limit: | 0.4% max |
| Potency (internal): | 730 IU/mg min |
| Bacterial endotoxins: | 0.5 IU/mg max |
| Sterility: | Complies |
| Streptomycin sulfate (dried substances): | 2.0% max |
Applications
1. Antibacterial Agent
Primarily used to treat bacterial infections caused by Gram-negative bacteria.
Effective against bacteria such as E. coli, Salmonella, Klebsiella, Pasteurella, and others.
2. Veterinary Medicine
Extensively applied in animal health care to treat bacterial infections in:
Cattle
Swine
Poultry
Sheep and goats
Used for treating infections like respiratory diseases, enteritis, and mastitis.
3. Combination Therapy
Often used in combination with other antibiotics (e.g., penicillins or tetracyclines) to broaden the antibacterial spectrum and prevent resistance.
4. Topical Formulations
Incorporated in topical ointments, sprays, and powders for treating infected wounds or skin infections in veterinary settings.
5. Research Use
Employed in microbiological and pharmaceutical research as a selective agent for bacterial growth or resistance studies.
Benefits
💪 Strong Bactericidal Activity
Inhibits protein synthesis by binding to the 30S subunit of bacterial ribosomes, leading to bacterial cell death.
🎯 Broad-Spectrum Coverage
Active against a wide range of aerobic Gram-negative bacilli, making it suitable for various infections in animals.
🐄 Essential for Livestock Health
Helps maintain productivity and health in livestock by treating infections that could impair growth, reproduction, or milk production.
🔄 Synergistic Effects
When used with other drugs (e.g., β-lactams), it can enhance efficacy and reduce required dosages of each drug.
🧫 Stability and Solubility
The sulfate salt form is highly soluble in water and stable in storage, making it suitable for injectable formulations.
📉 Resistance Management
As a derivative of streptomycin, it is effective even against some streptomycin-resistant bacterial strains.
Conclusion
Dihydrostreptomycin sulfate (CAS 5490-27-7) remains a valuable veterinary antibiotic known for its strong bactericidal activity, especially against Gram-negative pathogens. Its use in livestock contributes significantly to maintaining animal health and productivity. With good water solubility and stability, it is suitable for various formulations including injectables and topical products. Though no longer widely used in human medicine due to toxicity concerns, its role in veterinary applications and bacterial research remains important, especially when used responsibly to manage resistance and safeguard public health.
