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Specifications
| Appearance | White to brown powder |
| Assay (HPLC) | 98% min |
| Identification (HPLC) | The RT of the principal peak of the sample should match with that of the working standard |
| Specific rotation (1% in chloroform) | +44 to +55 °C |
| Loss on drying (Vacuum, 60 °C, 2 h) | 1.0% max |
| Single impurity | 0.5% max |
| Total impurity | 2.0% max |
Applications
2-Deoxy-2,2-difluoro-D-erythro-pentafuranous-1-ulose-3,5-dibenzoate (CAS 122111-01-7) is primarily utilized as an important intermediate in the synthesis of nucleoside analogues, especially gemcitabine, a widely used anticancer drug. Its chemical structure, featuring fluorine substitution and dibenzoate protection, makes it a valuable precursor in controlled reactions leading to highly active pharmaceutical ingredients (APIs). In addition to oncology-related drug development, it finds applications in research laboratories working on antiviral therapies, where nucleoside analogues play a central role in inhibiting viral replication. This compound is also employed in medicinal chemistry projects aimed at modifying sugar moieties to improve drug selectivity, stability, and bioavailability. Furthermore, its use extends to chemical process development and academic research, where it supports the study of fluorinated carbohydrates and their impact on therapeutic efficacy.
Benefits
The key benefits of using 2-Deoxy-2,2-difluoro-D-erythro-pentafuranous-1-ulose-3,5-dibenzoate lie in its ability to streamline drug synthesis and improve the efficiency of producing critical therapeutic compounds. Its fluorinated structure provides enhanced chemical stability, making it a reliable intermediate for large-scale pharmaceutical production. By serving as a protected form of a sugar derivative, it ensures selective reactions, reducing unwanted by-products and improving yields in complex syntheses. This not only lowers production costs but also supports consistent quality in drug development pipelines. From a research perspective, it enables exploration of new nucleoside-based drugs with potential applications against cancer and viral infections. Overall, it plays a pivotal role in bridging laboratory research with industrial pharmaceutical manufacturing, offering both scientific and commercial advantages.
Conclusion
In summary, 2-Deoxy-2,2-difluoro-D-erythro-pentafuranous-1-ulose-3,5-dibenzoate is a high-value compound that supports modern pharmaceutical innovation through its role as a key intermediate in nucleoside analogue synthesis. Its applications span oncology, antiviral drug development, and medicinal chemistry, while its benefits include enhanced process efficiency, chemical stability, and facilitation of targeted therapeutic research. As drug discovery continues to emphasize precision, selectivity, and scalability, this compound remains an indispensable tool in advancing both research and large-scale pharmaceutical production.
