Hangzhou Leap Chem Co., Ltd. is one of the most professional manufacturers and suppliers of 2,2-cyclouridine丨cas 3736-77-4 in China. Welcome to wholesale bulk high quality chemical products at competitive price from our factory. If you have any enquiry about custom service, please feel free to email us.
Specifications
| Appearance | White to off-white powder |
| Purity | 98.0% min |
| Loss on drying | 1.0% max |
Transport Information
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H.S. Code |
2938909090303 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature -20 °C Keep in a dry place. |
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Package |
Manufacturing Information
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Capacity |
2kg/month |
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Experience |
Production since 2016 |
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Applications
2,2-Cyclouridine is a specialized nucleoside analog widely used in medicinal chemistry, biochemistry, and nucleic acid research. Its unique cyclized structure distinguishes it from standard uridine, making it a valuable building block for the synthesis of modified oligonucleotides and RNA analogs. These modifications are critical in developing antiviral, anticancer, and gene-silencing therapeutics, where altered nucleosides can enhance stability, target specificity, or cellular uptake. In enzymology and molecular biology, 2,2-Cyclouridine is employed as a substrate or probe to investigate nucleoside-processing enzymes, including kinases, phosphorylases, and polymerases, providing insight into nucleotide metabolism and enzymatic mechanisms. Additionally, it is useful in chemical biology studies aimed at understanding RNA structure, folding, and interactions, as its cyclization can influence hydrogen bonding and base pairing in RNA motifs. The compound also serves as a precursor for more complex nucleoside derivatives that are explored in drug discovery programs and for synthetic biology applications.
Benefits
The distinct chemical structure of 2,2-Cyclouridine offers several advantages that make it attractive for research and pharmaceutical development. Its cyclized form provides enhanced chemical stability relative to unmodified uridine, reducing susceptibility to enzymatic degradation and hydrolysis. This stability enables more reliable incorporation into oligonucleotides, improving the durability of synthetic RNA or DNA constructs for in vitro and in vivo studies. The compound's modified nucleobase affects hydrogen bonding patterns, allowing researchers to fine-tune molecular recognition and interactions in nucleic acid assemblies. Its versatility in chemical modification facilitates the generation of a wide range of derivatives for structure-activity relationship studies, therapeutic exploration, and probe development. Furthermore, it aids in the design of nucleoside analogs with improved pharmacokinetic and pharmacodynamic profiles, enhancing their potential efficacy in antiviral or anticancer applications.
Conclusion
2,2-Cyclouridine is a highly valuable nucleoside analog that combines chemical stability with biological versatility. Its unique cyclized structure makes it an important tool for studying nucleoside metabolism, RNA structure, and enzyme activity while serving as a precursor for advanced drug design. By enabling the creation of modified oligonucleotides and nucleoside derivatives with enhanced stability and tailored biological interactions, it plays a crucial role in medicinal chemistry, chemical biology, and therapeutic research. Its combination of structural distinctiveness, chemical robustness, and functional adaptability ensures its continued relevance in both academic studies and pharmaceutical development.
