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Specifications
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Appearance |
White to off-white powder |
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Purity |
98.0% min |
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Water |
8.0% max |
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Solution Clarity Test |
Clear |
Transport Information
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Specification |
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UN Number |
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Class |
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Packing Group |
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H.S. Code |
2934999099305 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
-20℃ |
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Condition to Avoid |
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Package |
Manufacturing Information
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Parameter |
Specification |
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Capacity |
5kg/month |
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Frequency |
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Main Export Countries |
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Capacity/Batch |
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Experience |
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Stock |
Overview
2-Deoxyuridine 5-monophosphate disodium salt丨CAS 42155-08-8 (dUMP) is a mononucleotide composed of the nucleobase uracil, deoxyribose sugar, and phosphate group. It is a key intermediate in DNA synthesis and repair, and the precursor for the synthesis of thymidine monophosphate (TMP) via the enzyme thymidylate synthase. The disodium salt form enhances solubility and stability in aqueous solutions for biochemical and pharmaceutical applications.
Applications
1. DNA Synthesis and Metabolism Studies
Used in biochemical research to study the biosynthesis of thymidine nucleotides.
dUMP is the direct substrate for thymidylate synthase, an essential enzyme that methylates dUMP to form dTMP, a DNA building block.
2. Enzyme Assays
Acts as a substrate in thymidylate synthase activity assays, which are crucial for cancer research, given the enzyme's role in DNA replication.
3. Anticancer Drug Development
Since thymidylate synthase is a target for anticancer drugs (e.g., 5-fluorouracil), dUMP is used in studies evaluating enzyme inhibition, drug binding, and mechanistic analysis.
4. Cell Cycle and Apoptosis Studies
Manipulating dUMP levels in cells can influence DNA synthesis rates, making it useful in cell cycle regulation and apoptosis experiments.
5. Radiolabeling and Isotope Tracing
Radiolabeled forms of dUMP are used in DNA replication and repair pathway tracing, especially in molecular biology and pharmacokinetics.
Benefits
✅ Essential Metabolic Intermediate
Central to the de novo pyrimidine biosynthesis pathway, making it a key tool for fundamental metabolic research.
✅ Tool for Enzyme Inhibition Studies
Provides a direct substrate to assess inhibition of thymidylate synthase, a validated target in chemotherapy.
✅ Soluble and Stable Form
The disodium salt enhances aqueous solubility and makes it suitable for in vitro enzymatic reactions and cell-based assays.
✅ Non-toxic in Controlled Settings
As a natural metabolite, it can be used in controlled concentrations without significant toxicity in cell cultures.
✅ Versatile in Nucleic Acid Research
Useful for nucleotide incorporation studies, enzymatic conversion assays, and gene expression regulation experiments.
Summary
2-Deoxyuridine 5-monophosphate disodium salt丨CAS 42155-08-8 is a biologically important nucleotide used in DNA metabolism studies, particularly for investigating thymidylate synthase activity, DNA replication, and anticancer drug mechanisms. Its water-soluble disodium salt form makes it ideal for biochemical assays and therapeutic research.
