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Specifications
|
Appearance |
White to off-white powder, no visible foreign particles |
|
Purity (HPLC) |
99.5% min |
|
Clarity |
Colorless, clear solution. No insoluble particles |
|
Identification (HNMR) |
Conforms to the structure |
|
Water (KF) |
1% max |
|
Impurities (HPLC) - Total |
0.5% max |
|
Impurities (HPLC) - Individual |
0.05% max |
|
Residual Solvents (HNMR & GC) - Total |
1.0% max |
|
Methanol |
0.3% max |
|
Ethanol |
0.5% max |
|
N-Hexane |
0.029% max |
|
Ethyl acetate |
0.5% max |
|
Dichloromethane |
0.06% max |
|
Isopropanol |
0.3% max |
Overview
1-methylpseudouridine丨CAS 13860-38-3 is a modified nucleoside increasingly important in RNA-based therapeutics, especially mRNA vaccines. It is used to enhance RNA stability, reduce innate immune recognition, and improve translation efficiency in synthetic mRNA constructs. This molecule gained prominence as a key component of COVID-19 mRNA vaccines.
Applications
1. mRNA Vaccine Development
Widely used in synthetic mRNA vaccines, including those by Pfizer-BioNTech and Moderna.
Replaces uridine in the mRNA backbone to increase stability and translational efficiency.
Reduces activation of innate immune sensors (e.g., Toll-like receptors), making the mRNA less immunogenic and more effective.
2. mRNA Therapeutics & Gene Therapy
Incorporated into mRNA used for protein replacement therapy, genetic disorders, cancer immunotherapy, and regenerative medicine.
Helps avoid rapid mRNA degradation and enables sustained expression of therapeutic proteins.
3. Research on RNA Modifications
Used as a model compound in epitranscriptomics to study the function of naturally occurring RNA modifications, such as methylation and pseudouridylation.
4. Ribosome Profiling and Translation Studies
Helps researchers track ribosome movement on synthetic RNA and analyze codon usage, translation rates, and protein yield.
Benefits
✅ Improved Stability
1-methylpseudouridine丨CAS 13860-38-3 significantly increases the half-life of mRNA by enhancing its resistance to nuclease degradation.
✅ Enhanced Protein Translation
Boosts translation efficiency in both in vitro and in vivo systems, leading to higher protein expression levels.
✅ Reduced Immunogenicity
Modifies RNA to evade immune system detection, decreasing unwanted inflammatory responses-crucial for therapeutic use.
✅ High Biocompatibility
Well tolerated in human and animal cells, enabling safe delivery of functional mRNA without adverse side effects.
✅ Enables Next-Gen RNA Therapies
Central to the success of next-generation mRNA platforms for vaccines, gene editing, and cell reprogramming.
Summary
1-methylpseudouridine丨CAS 13860-38-3 is a synthetic RNA nucleoside that improves the stability, translational efficiency, and immunological profile of mRNA. Its pivotal role in mRNA vaccines, especially during the COVID-19 pandemic, marks it as a cornerstone of modern RNA medicine. It continues to enable innovation in vaccine development, gene therapy, and RNA-based drug design.
