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Specifications
| Appearance: | Yellow powder |
| Assay: | 98.0% min |
| Moisture: | 0.5% max |
Applications
1. Bioluminescent Imaging (BLI)
Widely used as a substrate for luciferase enzymes in in vivo and in vitro bioluminescent imaging.
Enables non-invasive monitoring of gene expression, tumor growth, infection progression, and cell tracking in live animals.
Essential in preclinical drug discovery and molecular biology research.
2. Reporter Gene Assays
Used in luciferase reporter assays to study promoter activity, gene regulation, and cell signaling pathways.
Provides highly sensitive quantification of biological processes.
3. High-Throughput Screening
Employed in drug screening platforms to evaluate enzyme activity, cell viability, and compound efficacy.
Bioluminescent readouts offer high sensitivity and low background noise.
4. Environmental and Biosensor Applications
Incorporated in biosensors for detecting ATP or other metabolites.
Used in microbial contamination detection and environmental monitoring.
Benefits
1. High Sensitivity and Specificity
Bioluminescence from D-luciferin-luciferase reaction has a low background, providing high signal-to-noise ratio.
Enables detection of very low levels of biological activity.
2. Non-Invasive and Real-Time Monitoring
Allows longitudinal studies of living systems without the need for euthanasia or tissue extraction.
Facilitates dynamic tracking of biological events in real time.
3. Versatile Compatibility
Compatible with multiple luciferase enzymes (firefly, click beetle, etc.).
Works in diverse biological systems including mammalian cells, bacteria, and whole animals.
4. Rapid and Quantitative
Produces an immediate light signal upon enzymatic reaction.
Enables rapid data acquisition and quantitative analysis.
5. Safe and Environmentally Friendly
Non-radioactive and relatively non-toxic at experimental doses.
Suitable for routine laboratory use.
Conclusion
D-Luciferin (CAS 2591-17-5) is the key bioluminescent substrate used in luciferase-catalyzed light-emitting reactions. Its applications span in vivo imaging, gene expression studies, drug screening, and biosensing. With its high sensitivity, low background, and non-invasive nature, D-luciferin is an indispensable tool in biomedical research, molecular biology, and pharmaceutical development.
