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Specifications of Imidazole hydrochloride丨CAS 1467-16-9
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Appearance: |
White or off-white crystals |
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Assay: |
97.0% min |
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Loss on drying: |
0.5% max |
Transport Information of Imidazole hydrochloride丨CAS 1467-16-9
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Parameter |
Specification |
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UN Number |
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Class |
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Packing Group |
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H.S. Code |
2933290090302 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions (room temperature). |
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Storage |
Tightly closed. Dry. hygroscopic |
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Condition to Avoid |
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Package |
Imidazole hydrochloride丨CAS 1467-16-9 is the hydrochloride salt of imidazole, a five-membered aromatic heterocycle containing two nitrogen atoms. This compound is more stable and water-soluble than imidazole itself, making it useful in various biochemical, pharmaceutical, and industrial applications.
Key Applications of Imidazole hydrochloride丨CAS 1467-16-9
1. Biochemical Buffering Agent
Imidazole hydrochloride丨CAS 1467-16-9 is commonly used as a buffering agent in protein purification, especially in nickel-affinity chromatography (His-tag purification). It helps maintain a stable pH and elutes histidine-tagged proteins by competing for binding sites on the metal ion column.
2. Pharmaceutical Intermediate
This compound serves as a synthetic intermediate in the production of antifungal agents, anti-inflammatory drugs, and other imidazole-based pharmaceuticals. Its enhanced solubility in water facilitates use in aqueous reaction systems.
3. Enzyme and Protein Studies
Imidazole derivatives are known to mimic histidine residues in enzyme active sites. Imidazole hydrochloride is employed in research to investigate enzyme mechanisms, catalysis, and protein-ligand interactions.
4. Chemical Synthesis and Catalysis
In organic synthesis, imidazole hydrochloride acts as a precursor or catalyst for creating imidazole-containing compounds. It is also involved in heterocyclic synthesis and peptide coupling reactions.
5. Coordination Chemistry
Due to its nitrogen-rich structure, imidazole hydrochloride is used in coordination chemistry to prepare metal complexes, which are studied for their catalytic, magnetic, or electronic properties.
Benefits of Imidazole hydrochloride丨CAS 1467-16-9
✅ Enhanced Water Solubility
Compared to free imidazole, the hydrochloride salt dissolves more readily in water, making it more practical in biological and aqueous chemical processes.
✅ Biocompatibility
Non-toxic at working concentrations, imidazole hydrochloride is suitable for biological assays, especially those involving proteins and enzymes.
✅ Versatile Usage
Its roles range from buffering and ligand preparation to drug precursor, offering broad utility in lab and industrial settings.
