D-(+)-Mannose丨CAS 3458-28-4

D-(+)-Mannose, with the Chemical Abstracts Service (CAS) number 3458-28-4, is a naturally occurring monosaccharide and a C-2 epimer of glucose. It is a simple sugar that plays important roles in human metabolism and glycobiology. D-(+)-Mannose丨3458-28-4 is found in various fruits and plants and is also synthesized for use in medical, nutritional, and research applications.

Chemical Properties

- Melting Point: ~132°C (270°F)

- Solubility: Highly soluble in water, slightly soluble in ethanol.

- Structure: A hexose sugar with the same molecular formula as glucose but differs in the orientation of the hydroxyl group at the second carbon.

1. Medical and Therapeutic Uses:

- Urinary Tract Health: D-(+)-Mannose is widely used as a natural supplement to support urinary tract health. It helps prevent and manage urinary tract infections (UTIs) by inhibiting the adhesion of Escherichia coli bacteria to the urinary tract lining.

- Glycosylation Disorders: It is used in the treatment of certain congenital disorders of glycosylation (CDGs), where it serves as a supplement to correct metabolic deficiencies.

2. Nutritional Supplements:

- D-(+)-Mannose is marketed as a dietary supplement for its potential health benefits, including immune system support and promoting gut health by acting as a prebiotic.

3. Glycobiology Research:

- D-(+)-Mannose is a key component of glycoproteins and glycolipids, which are essential for cell-cell communication and immune function. It is used in research to study glycosylation processes and their role in health and disease.

- It is also used to synthesize complex carbohydrates and glycoconjugates for biochemical studies.

4. Pharmaceuticals:

- D-(+)-Mannose is used in the development of drugs and vaccines, particularly those targeting bacterial infections. Its ability to block bacterial adhesion makes it a promising candidate for anti-infective therapies.

5. Food Industry:

- It is used as a low-calorie sweetener and stabilizer in food products. D-(+)-Mannose is also added to functional foods and beverages for its potential health benefits.

6. Cosmetics:

- D-(+)-Mannose is used in skincare products for its moisturizing and soothing properties. It helps improve skin hydration and barrier function.

1. UTI Prevention and Management:

- D-(+)-Mannose is highly effective in preventing and treating UTIs caused by E. coli. It works by binding to the bacteria and preventing them from adhering to the urinary tract walls, allowing them to be flushed out with urine.

2. Safety and Tolerability:

- D-(+)-Mannose is generally safe and well-tolerated, with minimal side effects. It is a natural sugar that does not significantly affect blood glucose levels, making it suitable for individuals with diabetes.

3. Metabolic Support:

- It plays a role in glycosylation, a critical process for the proper functioning of proteins and lipids in the body. Supplementation with D-(+)-Mannose can help correct metabolic imbalances in certain genetic disorders.

4. Gut Health:

- As a prebiotic, D-(+)-Mannose promotes the growth of beneficial gut bacteria, supporting digestive health and immune function.

5. Research Utility:

- Its role in glycobiology makes D-(+)-Mannose a valuable tool for studying cellular processes, immune responses, and disease mechanisms.

- D-(+)-Mannose丨3458-28-4 is considered safe for consumption and use in various applications. However, excessive intake may cause mild gastrointestinal discomfort, such as bloating or diarrhea.

- It should be stored in a cool, dry place, away from moisture and direct sunlight, to maintain its stability.

D-(+)-Mannose丨3458-28-4 is a versatile and biologically significant sugar with applications in medicine, nutrition, research, and industry. Its ability to support urinary tract health, promote gut health, and serve as a research tool in glycobiology underscores its importance in both health and science. As a safe and natural compound, D-(+)-Mannose continues to gain attention for its therapeutic potential and wide-ranging benefits.