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Specifications
|
Grade |
FCCVIII |
|
Description |
White crystals or crystalline powder |
|
Assay |
98.5~101.5% |
|
Specific rotation |
-84.3° to -86.3° |
|
pH |
5.9~6.9 |
|
Chloride (Cl) |
0.05% max |
|
Ammonium salt |
0.02% max |
|
Sulfate (SO4) |
0.02% max |
|
Iron (Fe) |
0.001% max |
|
Heavy metals (Pb) |
0.0015% max |
|
Loss on drying |
0.5% max |
|
Residue on ignition |
0.2% max |
|
Aerobic Plate Count |
1000 CFU/g max |
|
Yeast & moulds |
100 CFU/g max |
Applications
1. Biochemistry and Molecular Biology
Integral component of proteins and peptides, particularly abundant in collagen, contributing to its unique structure and stability.
Used in peptide synthesis and as a building block in protein engineering and enzyme design.
2. Pharmaceutical Industry
Employed in the synthesis of chiral drugs and as a chiral auxiliary or ligand in asymmetric synthesis to produce optically pure compounds.
Important in developing proline-based inhibitors and therapeutics targeting specific enzymes.
3. Food Industry
Used as a nutritional supplement and flavor enhancer.
Serves as a stabilizer and functional additive in food formulations.
4. Cosmetics and Personal Care
Included in formulations for its hydrating and skin-conditioning properties, aiding in maintaining skin elasticity and moisture.
5. Chemical Synthesis
Acts as a chiral catalyst in organic synthesis, particularly in enantioselective reactions such as aldol reactions and Michael additions.
Utilized in the preparation of organocatalysts for green and sustainable chemistry.
Benefits
1. Structural Role in Proteins
L-(-) Proline丨CAS 147-85-3 induces kinks and turns in polypeptide chains, influencing protein folding and stability, essential in collagen and other structural proteins.
2. Chirality and Catalysis
Its unique cyclic structure imparts rigidity and stereochemical control in catalytic applications, enhancing the production of enantiomerically pure compounds.
3. Biocompatibility and Safety
Naturally occurring amino acid, non-toxic, and safe for use in pharmaceutical, food, and cosmetic products.
4. Versatility
Multifunctional uses spanning from biochemical research to industrial synthesis make L-proline highly valuable.
5. Environmental Friendliness
Supports green chemistry practices through organocatalysis, reducing reliance on heavy metals and harsh reagents.
Conclusion
L-(-) Proline丨CAS 147-85-3 is a fundamental amino acid with pivotal roles in protein structure, pharmaceutical synthesis, and catalysis. Its unique cyclic structure and chiral properties enable diverse applications across biochemistry, medicine, food, and green chemistry. Its natural abundance, safety, and effectiveness make it indispensable in both research and industry.
