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Specifications
| Appearance: | White crystalline powder |
| Identification: | A: IR, B: UV, C: TLC |
| UV Absorption (281 nm): | Calculated on the dried basis, do not differ by more than 3.0% |
| Solubility: | Practically insoluble in water; soluble in alcohol, acetone, dioxane, chloroform; sparingly soluble in vegetable oils |
| Loss on drying: | 0.50% max |
| Melting point: | About 110℃ |
| Total related substances: | 2.0% max |
| Any individual impurity: | 0.50% max |
| Residue on ignition: | 0.10% max |
| Purity: | 99.0% min |
Applications
Estradiol undecylate is a long-acting estrogen ester widely used in hormone therapy, endocrine research, and veterinary medicine. Its primary application is in hormone replacement therapy (HRT) for conditions related to estrogen deficiency, such as menopause, osteoporosis prevention, and certain cases of hypogonadism. The undecylate ester prolongs the release of estradiol after intramuscular injection, allowing for sustained estrogenic activity over weeks, which improves patient compliance and reduces dosing frequency. In veterinary applications, estradiol undecylate is used for growth regulation, reproductive management, and estrus synchronization in livestock. Additionally, it serves as a reference standard and intermediate in pharmaceutical research for the development of novel estrogen derivatives and formulations, supporting studies on receptor interactions, metabolic stability, and pharmacokinetics.
Benefits
The benefits of estradiol undecylate arise from its long-acting profile, predictable pharmacokinetics, and effective estrogenic activity. The undecylate esterification significantly extends the compound's half-life, enabling slow and steady hormone release, which maintains stable serum estradiol levels and minimizes peak-trough fluctuations that could cause side effects. Its high bioavailability and potent estrogenic effect provide effective therapeutic outcomes for HRT and other medical uses. Estradiol undecylate also allows for less frequent dosing compared to free estradiol, improving patient adherence and convenience. Additionally, it demonstrates strong compatibility with injection formulations, ensuring consistent absorption and reproducible results in clinical and veterinary applications. Its well-characterized safety profile further supports its use in controlled therapeutic and research settings.
Conclusion
Estradiol undecylate (CAS 3571-53-7) is a valuable long-acting estrogen ester used in hormone therapy, veterinary medicine, and pharmaceutical research. Its extended-release profile, potent estrogenic activity, and predictable pharmacokinetics make it an effective and convenient option for managing estrogen-related conditions. By providing sustained hormone levels, improved patient compliance, and reliable therapeutic outcomes, estradiol undecylate continues to be an essential compound in clinical and research applications related to estrogen biology.
