DL-Cycloserine丨CAS 68-39-3

DL-Cycloserine is a broad-spectrum antibiotic and neuroactive compound widely used in pharmaceutical research, clinical studies, and neuroscience investigations. In medical and pharmaceutical contexts, it has been applied in the treatment of tuberculosis and certain bacterial infections by inhibiting cell wall synthesis. In neuroscience and psychiatric research, DL-cycloserine is extensively studied as a partial agonist of the NMDA receptor, where it is used to investigate learning, memory, fear extinction, and synaptic plasticity. It is commonly incorporated into experimental protocols for anxiety disorders, post-traumatic stress disorder, and cognitive enhancement studies. In microbiological research, DL-cycloserine is used to evaluate bacterial resistance mechanisms, screen antimicrobial agents, and study peptidoglycan biosynthesis. It is also applied as a reference compound in pharmacological assays and drug development programs.

The benefits of DL-cycloserine arise from its dual pharmacological and research value, well-characterized mechanism of action, and experimental versatility. As an antibiotic, it inhibits alanine racemase and D-alanine ligase, disrupting bacterial cell wall formation and leading to effective growth suppression. In neuroscience applications, its NMDA receptor modulation supports controlled investigation of cognitive and behavioral processes. The racemic mixture provides consistent availability and standardized performance in research settings. DL-cycloserine exhibits good water solubility, enabling easy formulation and accurate dosing in laboratory and clinical studies. Its stability under recommended storage conditions ensures reproducibility and long-term usability.