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Specifications
| Appearance: | Yellow to off white powder |
| Purity (HPLC): | 98% min |
| Clarity of solution: | 0.1 gram in 2ml DMF clear solution |
| Water Content (K.F.): | 1.0% max |
| Loss on drying: | 1.0% (50℃, 2h) |
| IR Spectrum: | In accordance with the structure |
| Mass Spectrum: | In accordance with the structure |
| NMR Spectrum: | In accordance with the structure |
| Melting Point: | 135.8-136.7℃ |
| Specific Rotation [α]20D: | -4.1° (C=1 in DMF) |
Applications
BOC-ARG(Z)2-OH is a protected amino acid derivative widely used in peptide synthesis and medicinal chemistry. It serves as a building block for the stepwise construction of peptides and peptidomimetics, particularly arginine-rich sequences. The BOC (tert-butyloxycarbonyl) group protects the amino terminus, while the Z (benzyloxycarbonyl) groups protect the guanidino side chain of arginine, enabling selective deprotection and coupling during solid-phase or solution-phase peptide synthesis. This compound is commonly applied in the preparation of bioactive peptides, enzyme inhibitors, therapeutic peptides, and research compounds. It is also used in the development of peptide libraries, screening of protein interactions, and synthesis of peptide-based drugs.
Benefits
The compound offers several advantages due to its dual protection strategy. The BOC and Z groups provide excellent stability under standard coupling conditions, preventing undesired side reactions during multi-step synthesis. This allows precise control over peptide chain elongation and side-chain functionality. The derivative is compatible with common peptide coupling reagents and solvents, facilitating efficient synthesis with high yield and purity. Additionally, the protected arginine maintains its chemical integrity until selective deprotection, enabling researchers to design complex peptides with multiple functional residues and ensuring reproducibility in both research and industrial peptide synthesis.
Conclusion
BOC-ARG(Z)2-OH is a valuable protected amino acid derivative essential for the synthesis of arginine-containing peptides and peptidomimetics. Its dual protection strategy enhances stability, selectivity, and efficiency in multi-step peptide assembly. By providing precise control over peptide construction, it supports the development of bioactive peptides, therapeutic agents, and research compounds, making it indispensable in peptide chemistry and pharmaceutical research.
