1,1'-Biphenyl, 3-iodo-丨CAS 20442-79-9

1. Suzuki–Miyaura Coupling Reactions

One of the most common uses for aryl iodides.

Reacts with boronic acids/esters to form C–C bonds, enabling the synthesis of biaryl and polyaryl compounds.

Suitable for synthesis of functionalized biphenyls, ligands, pharmaceuticals, and polymers.

2. Materials Science

Intermediate for preparing OLED emitters, conjugated polymers, and liquid crystals.

The biphenyl core offers rigidity and π-conjugation, useful in tuning optical/electronic properties.

3. Pharmaceutical & Agrochemical Intermediate

Starting material for making biologically active compounds.

Enables the introduction of various functional groups through iodine displacement.

4. Directed C–H Functionalization

The iodine group serves as a handle for regioselective C–H activation, allowing access to otherwise difficult substitution patterns.

✅ Highly Reactive Iodine Substituent

Iodine is a superior leaving group, making it ideal for Pd-catalyzed reactions and other nucleophilic substitutions.

✅ Structural Versatility

The biphenyl skeleton is a key motif in drug design, ligands, and materials. This compound is useful for diversifying biphenyl-based libraries.

✅ Efficient Intermediate

Provides a modular route to larger conjugated systems or functional molecules with precise substitution patterns.

✅ Stability and Storage

Stable under normal conditions, easy to store and handle in standard organic synthesis labs.