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Specifications
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Appearance: |
Light yellow liquid or white crystal |
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Purity: |
99% min |
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Single impurity: |
0.2% max |
Transport Information
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Parameter |
Specification |
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UN Number |
1325 |
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Class |
4; 8 |
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Packing Group |
II |
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H.S. Code |
2908199090305 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Tightly closed. Keep away from heat and sources of ignition. |
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Condition to Avoid |
Heating |
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Package |
Manufacturing Information
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Parameter |
Specification |
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Capacity |
1MT/year |
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Frequency |
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Main Export Countries |
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|
Capacity/Batch |
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Experience |
Production since 2015 |
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Stock |
Chemical Structure & Description
3,4-Difluorophenol丨CAS 2713-33-9 is a fluorinated aromatic compound featuring a phenol ring substituted with fluorine atoms at the 3 and 4 positions. The presence of the electron-withdrawing fluorine atoms significantly modifies the reactivity, acidity, and lipophilicity of the phenol group, making it an important intermediate in medicinal chemistry and fine chemical synthesis.
Applications
1. Pharmaceutical Intermediate
Widely used in the synthesis of active pharmaceutical ingredients (APIs) and bioactive compounds.
The difluoro substitution enhances metabolic stability and binding affinity in drug candidates.
Acts as a precursor or building block in the preparation of anti-inflammatory, antiviral, or oncological agents.
2. Agrochemical Synthesis
Used in the design and manufacture of herbicides, fungicides, and insecticides.
The fluorinated phenol core improves the environmental persistence and biological activity of agrochemicals.
3. Organic Synthesis
Serves as a key electrophilic aromatic intermediate.
Used in nucleophilic aromatic substitution (SNAr) reactions and cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
Can be further functionalized at the phenol or aromatic positions for advanced synthetic routes.
4. Material Science
Used in the synthesis of fluorinated polymers or resins where chemical resistance, thermal stability, and hydrophobicity are needed.
Acts as a monomer or additive for specialty coatings and electronic materials.
Benefits
Fluorine substitution increases lipophilicity, electron-withdrawing effect, and stability.
Provides access to a wide range of functionalized aromatic compounds.
The phenol group offers reactive flexibility (e.g., etherification, esterification, coupling).
Summary
3,4-Difluorophenol丨CAS 2713-33-9 is a valuable fluorinated aromatic intermediate used in pharmaceuticals, agrochemicals, organic synthesis, and specialty materials. Its electron-deficient phenol ring allows for targeted reactivity and improved biological properties in end-use compounds. Its utility in modern synthesis stems from the versatility provided by the difluoro substitution pattern and the reactive phenolic group.
Let me know if you need example reactions or derivatives synthesized from this compound.
