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Specifications
| Grade | EP9 |
| Appearance | White crystalline powder |
| Assay | 99.0~101.0% |
| Clarity and colour of solution | Clear and colour ≤ Y6 |
| Acidity | pH 6.0~6.8 |
| Loss on drying | 6.0~10.0 |
| Specific optical rotation | -245° to -258° |
| Any other quinine | Conform |
| Distinguish | Conform |
| Sulphated ash | 0.1% max |
| Barium | No turbidity produced |
| Sulphate | 500 ppm max |
| Solubility | Slightly soluble in water, freely soluble in methanol |
Applications
Quinine hydrochloride is primarily used in pharmaceutical formulations as an antimalarial and antipyretic agent. It is applied in the treatment of malaria, particularly in cases caused by Plasmodium falciparum where resistance to other therapies may be present. The compound is also utilized for managing nocturnal leg cramps and certain febrile conditions due to its muscle-relaxant and fever-reducing properties. In laboratory and research settings, quinine hydrochloride serves as a reference compound in pharmacological studies and fluorescence research. Additionally, it is used as a bittering agent in flavor research and analytical testing.
Benefits
Quinine hydrochloride offers strong therapeutic efficacy due to its well-characterized pharmacological activity. Its hydrochloride salt form enhances water solubility, facilitating formulation in oral and injectable dosage forms. The compound demonstrates reliable bioavailability and a rapid onset of action, which is important in acute treatment scenarios. Quinine hydrochloride has a long history of clinical use, providing extensive data on dosing, safety, and effectiveness. Its chemical stability supports consistent performance during manufacturing and storage, while its versatility allows use in both clinical and research applications.
Conclusion
Quinine hydrochloride is a well-established compound with important pharmaceutical and research applications. Its effectiveness in malaria treatment, improved solubility as a hydrochloride salt, and proven stability make it a valuable active ingredient. With a long record of use and broad functional utility, quinine hydrochloride remains relevant in modern pharmaceutical development and scientific research.
