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Specifications
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Appearance |
Colorless to light yellow liquid |
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Assay |
99.2% min. |
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Methyl formate |
0.2% max. |
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Methanol |
0.3% max. |
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Water |
0.05% max. |
Transport Information
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UN Number |
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Class |
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Packing Group |
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H.S. Code |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Tightly closed. Store in a closed, dry, ventilated place |
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Condition to Avoid |
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Package |
Manufacturing Information
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Parameter |
Specification |
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Capacity |
30,000MT/year |
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Frequency |
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Main Export Countries |
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Capacity/Batch |
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Experience |
Production since 2007 |
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Stock |
Overview
Trimethoxymethane丨CAS 149-73-5 (also known as trimethyl orthoformate) is a clear, colorless liquid with the formula HC(OCH3)3. It is an orthoester commonly used as a reagent in organic synthesis due to its ability to serve as a source of the formyl or methoxy group.
Applications
Organic Synthesis Reagent
Used as a formylating agent to introduce formyl groups (–CHO) into organic molecules.
Commonly employed in the synthesis of heterocycles, pharmaceuticals, and fine chemicals.
Acetal and Orthoester Formation
Reacts with aldehydes and ketones to form acetals and orthoesters, protecting groups in synthetic chemistry.
Protects carbonyl functionalities during multi-step syntheses.
Solvent and Extractant
Occasionally used as a solvent or extractant for polar organic compounds due to its polar nature.
Intermediate in Fine Chemicals
Used in the manufacture of dyes, perfumes, and other specialty chemicals.
Fuel Additive
Sometimes investigated as an oxygenate additive to improve combustion and reduce emissions in fuels.
Benefits
High Reactivity and Selectivity
Trimethoxymethane丨CAS 149-73-5 is highly reactive toward nucleophiles and carbonyl compounds, allowing efficient functional group transformations.
Mild Reaction Conditions
Enables acetal and orthoester formation under relatively mild and controlled conditions.
Volatile and Easily Removable
Due to its relatively low boiling point (~81°C), it can be easily removed after reaction completion, simplifying purification.
Versatile Synthetic Building Block
Its multifunctionality makes it valuable in diverse synthetic pathways, including the pharmaceutical industry.
