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Specifications
| Appearance | Colorless transparent liquid |
| Assay | 99.5% min |
| Sulphate | 0.05% max |
| Fluoride | 0.005% max |
| Chloride | 0.05% max |
| Moisture Content | 0.05% max |
Transport Information
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Parameter |
Specification |
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UN Number |
2699 |
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Class |
8 |
|
Packing Group |
I |
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H.S. Code |
2915900090 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
|
Storage |
Keep container tightly closed. Store in a cool and shaded area. Protect from moisture. Keep under inert gas. Store locked up. |
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Condition to Avoid |
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Package |
Applications
Trifluoroacetic acid (CAS 76-05-1) is a strong, highly fluorinated carboxylic acid widely used in organic synthesis, peptide chemistry, and analytical applications. It is a common reagent for deprotecting Fmoc- and t-butyl-based protecting groups in peptide synthesis, enabling efficient removal without damaging sensitive functional groups. Trifluoroacetic acid is also used as a solvent or acid catalyst in various chemical reactions, including esterification, acylation, and condensation processes. In analytical chemistry, it serves as an ion-pairing agent in high-performance liquid chromatography (HPLC) and mass spectrometry, improving separation and detection of peptides, proteins, and other polar compounds. Additionally, it is employed in the preparation of trifluoroacetate salts and as a fluorine source for introducing trifluoromethyl groups into target molecules.
Benefits
The benefits of trifluoroacetic acid arise from its strong acidity, volatility, and compatibility with a wide range of chemical systems. Its high acidity allows efficient cleavage of acid-labile protecting groups and catalysis of various organic reactions under mild conditions. Being volatile, it can be easily removed after reactions, reducing contamination of products and simplifying work-up procedures. Its solubility in organic solvents and water makes it versatile for multiple reaction media, while its stability ensures reliable performance in synthesis and analytical applications. These properties make trifluoroacetic acid an indispensable reagent in peptide synthesis, organic chemistry, and analytical workflows, providing reproducible results and high efficiency.
Conclusion
Trifluoroacetic acid is a versatile and powerful reagent used in peptide synthesis, organic reactions, and analytical chemistry. Its strong acidity, volatility, and solvent compatibility enable efficient deprotection, catalysis, and analysis of complex molecules. By supporting high-performance synthesis and accurate analytical methods, trifluoroacetic acid remains a critical tool in modern chemical research and industrial applications.
