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Specifications of 4-Fluoroaniline丨CAS 371-40-4
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Appearance |
Colorless to reddish brown and transparent liquid, slightly soluble in water |
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Content |
99.5% min |
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Water |
0.2% max |
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Impurity |
0.2% max |
Transport Information of 4-Fluoroaniline丨CAS 371-40-4
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Parameter |
Specification |
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UN Number |
2941 |
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Class |
6.1 |
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Packing Group |
III |
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H.S. Code |
2921420090307 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions (room temperature). |
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Storage |
Tightly closed. Store in a closed, dry, ventilated place |
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Condition to Avoid |
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Package |
Manufacturing Information of 4-Fluoroaniline丨CAS 371-40-4
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Parameter |
Specification |
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Capacity |
50MT/year |
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Frequency |
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Main Export Countries |
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Capacity/Batch |
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Experience |
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Stock |
4-Fluoroaniline丨CAS 371-40-4 (also known as p-fluoroaniline) is an aromatic amine that consists of a benzene ring substituted with a fluorine atom at the para-position and an amino group (-NH₂). It is a colorless to pale yellow liquid that is moderately soluble in water and more soluble in organic solvents.
Key Applications of 4-Fluoroaniline丨CAS 371-40-4
1. Pharmaceutical Intermediates
● Used in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
● Serves as a building block for aniline-based drug molecules, particularly in analgesics, anti-inflammatory drugs, and antidepressants.
2. Agrochemical Intermediates
● 4-Fluoroaniline丨CAS 371-40-4 Acts as a precursor in the synthesis of herbicides, fungicides, and insecticides.
● Its functionalized aromatic structure allows for tailored agrochemical properties.
3. Dye and Pigment Manufacturing
● Used in the production of azo dyes, fluorinated colorants, and specialty pigments.
● Enhances colorfastness, UV resistance, and chemical stability of the resulting dyes.
4. Specialty Polymers and Resins
● Employed in the synthesis of fluorinated monomers for engineering plastics, coatings, and high-performance materials.
● Fluorinated moieties improve chemical resistance and thermal stability.
5. Organic Synthesis and Research
● Commonly used in structure–activity relationship (SAR) studies to investigate the effect of fluorine substitution on aromatic amines.
● Functions as a nucleophilic reagent or substituted aniline in the formation of heterocycles, Schiff bases, and azo compounds.
Benefits of 4-Fluoroaniline丨CAS 371-40-4
✅ Fluorine-Enhanced Properties
● The fluorine atom modulates electronic properties, leading to increased metabolic stability and bioavailability in drug and agrochemical design.
✅ Reactivity for Derivatization
● The amino group provides a versatile handle for nucleophilic substitution, amide formation, and diazotization.
✅ Useful in Material Science
● Enhances thermal and chemical resistance in high-performance polymers and coatings.
✅ Synthetic Versatility
● Offers a functionalized aromatic ring, enabling downstream synthesis of complex molecules.
Conclusion
4-Fluoroaniline丨CAS 371-40-4 is a valuable chemical intermediate used widely in the pharmaceutical, agrochemical, and dye industries, as well as in research and advanced material development. Its dual functionality-an amino group and a para-fluorine substituent-offers a powerful combination for synthetic chemists looking to tailor molecular properties in various applications.
