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Specifications
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Appearance |
Clear or light yellow liquid |
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Water |
0.3% max |
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Content |
99.5% min |
Transport Information
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Specification |
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UN Number |
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Class |
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Packing Group |
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H.S. Code |
2903999090306 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Tightly closed. Store in a closed, dry, ventilated place |
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Condition to Avoid |
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Package |
Manufacturing Information
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Parameter |
Specification |
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Capacity |
5MT/month |
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Frequency |
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Main Export Countries |
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Capacity/Batch |
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Experience |
Production since 2000 |
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Stock |
Applications
1. Pharmaceutical Intermediate
● Used as a building block in the synthesis of active pharmaceutical ingredients (APIs).
● Facilitates the development of fluorinated and halogenated aromatic scaffolds, which are common in antiviral, oncology, and CNS drugs.
● Valuable in the design of compounds with enhanced metabolic stability and membrane permeability.
2. Agrochemical Synthesis
● Intermediate in the preparation of herbicides, fungicides, and insecticides.
● Halogenated aromatic compounds are key structural motifs in crop protection agents, offering improved bioactivity and environmental persistence.
3. Material Science and Specialty Polymers
● 4-Bromo-1-chloro-2-fluorobenzene丨CAS 60811-18-9 is used in the synthesis of fluorinated monomers and functional materials, especially in liquid crystals, OLEDs, and high-performance plastics.
● Halogenated aromatics improve thermal stability, chemical resistance, and electronic properties of polymers.
4. Organic Synthesis Reagent
● Useful in cross-coupling reactions (e.g., Suzuki, Stille, Negishi) as a halogenated aromatic partner:
o Bromine offers high reactivity.
o Fluorine can modulate electron density and physicochemical properties.
● Enables the introduction of multiple halogen atoms into target molecules, aiding in SAR (Structure–Activity Relationship) studies.
Benefits
1. Versatile Halogenated Substrate
● The presence of three different halogens (Br, Cl, F) provides regioselective reactivity, allowing for:
o Sequential substitution or functionalization
o Fine-tuning of chemical and biological properties
2. Enhanced Molecular Properties
● Fluorine improves:
o Lipophilicity
o Metabolic stability
o Binding affinity in bioactive compounds
● Bromine and chlorine facilitate selective C–C bond formation in synthesis pipelines.
3. Synthetic Accessibility
● Commercially available and compatible with a wide range of synthetic methodologies, from aromatic substitution to metal-catalyzed coupling.
● Serves as a cost-effective starting point for high-value compound libraries.
Conclusion
4-Bromo-1-chloro-2-fluorobenzene丨CAS 60811-18-9 is a strategically halogenated aromatic compound offering excellent reactivity and versatility across multiple industries. Whether used as a pharmaceutical or agrochemical intermediate, a material science precursor, or a reagent in organic synthesis, it provides chemists with a highly functional building block for advanced chemical and molecular engineering.
