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Specifications
|
Appearance |
Colorless liquid |
|
Purity (by GC) |
98% min |
|
Total impurity (%) |
2% max |
Overview
1,3,5-Tris(trifluoromethyl)benzene丨CAS 729-81-7 is an aromatic compound featuring three trifluoromethyl (-CF₃) groups symmetrically substituted on a benzene ring at the 1,3,5-positions. The trifluoromethyl groups impart strong electron-withdrawing characteristics and increase the compound's lipophilicity and chemical stability.
Applications
1. Pharmaceutical and Agrochemical Intermediates
Used as a building block or intermediate in the synthesis of pharmaceutical agents and agrochemicals.
The trifluoromethyl groups enhance the biological activity and metabolic stability of compounds derived from this building block.
2. Specialty Chemical Synthesis
Serves as a precursor or reagent for incorporating trifluoromethyl groups into more complex molecules via substitution or cross-coupling reactions.
Useful in the development of fluorinated materials with enhanced chemical and thermal resistance.
3. Materials Science
Employed in the design of fluorinated polymers or materials requiring high chemical stability and hydrophobicity.
4. Analytical Chemistry
Used as a reference or standard compound in fluorine-19 NMR spectroscopy due to its distinctive CF₃ signals.
Benefits
✅ High Chemical Stability
The trifluoromethyl groups confer resistance to oxidation, hydrolysis, and metabolic degradation.
✅ Electron-Withdrawing Effect
Useful for tuning electronic properties in molecules, affecting reactivity and binding affinity in drug design.
✅ Thermal Stability
Stable at elevated temperatures, which is beneficial for industrial chemical processes.
✅ Hydrophobicity
Increased lipophilicity can improve solubility in organic media and biological membranes for bioactive compounds.
Summary
1,3,5-Tris(trifluoromethyl)benzene丨CAS 729-81-7 is a valuable fluorinated aromatic compound widely used as an intermediate in pharmaceuticals, agrochemicals, and specialty materials. Its trifluoromethyl groups enhance chemical stability and electronic properties, making it a key reagent in advanced chemical synthesis.
