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Specifications
| Appearance | White powder |
| Purity (HPLC) | 98.0% min |
| Identification (HNMR, MS) | Spectrum of sample corresponds to that of R.S. |
Applications
1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) is a saturated phospholipid widely used in liposome formulation, drug delivery, nanomedicine, and membrane biophysics research. It is a key component in the preparation of stable liposomes, particularly when long-circulation or high-temperature stability is required due to its high phase transition temperature. DSPE is frequently employed in the development of lipid nanoparticles (LNPs) and liposomal drug carriers for delivering small molecules, peptides, nucleic acids, and imaging agents. It is also used as a structural lipid in PEGylated phospholipoids such as DSPE-PEG derivatives, which enable steric stabilization and controlled surface modification of nanoparticles. In biological research, DSPE serves as a model lipid for studying membrane dynamics, phase behavior, protein–lipid interactions, and the formation of supported lipid bilayers. It is also applied in diagnostic formulation, sustained-release technologies, and the creation of biomimetic materials.
Benefits
DSPE offers significant advantages owing to its structural stability, biocompatibility, and versatility in formulation design. Its saturated stearoyl chains confer strong packing integrity and high thermal stability, making DSPE-containing liposomes more resistant to leakage, degradation, and environmental stress. The presence of a primary amine on the phosphoethanolamine headgroup allows chemical modification, enabling the creation of functionalized lipids or conjugation with PEG, ligands, or targeting moieties. DSPE-based nanoparticles exhibit long shelf stability, predictable behavior, and reproducible performance in both laboratory and industrial formulations. Its excellent biocompatibility and minimal immunogenicity make it suitable for therapeutic use, enhancing the safety profile of drug delivery systems. The ability to form robust bilayers also supports consistent encapsulation efficiency, controlled release, and improved pharmacokinetics in various therapeutic applications.
Conclusion
1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (CAS 1069-79-0) is a high-value phospholipid essential in modern drug delivery, nanomedicine, and membrane research. Its structural rigidity, functionalization potential, and excellent biocompatibility make it an ideal component for stable liposomes, lipid nanoparticles, and advanced biomedical formulations. Through its reliability, tunability, and strong performance in both experimental and applied settings, DSPE continues to play a vital role in the design of efficient and durable delivery systems and in advancing membrane-related scientific studies.
