(2S)-1-(1R)-1-(Dimethylamino)ethyl-2-(diphenylphosphino)ferrocene丨CAS 74311-54-9

(2S)-1-(1R)-1-(Dimethylamino)ethyl-2-(diphenylphosphino)ferrocene is a chiral ferrocene-based phosphine ligand widely used in asymmetric catalysis and organometallic chemistry. Its unique combination of a ferrocene backbone, a phosphine moiety, and a chiral dimethylaminoethyl substituent allows the formation of highly enantioselective metal complexes with palladium, rhodium, ruthenium, and other transition metals. These metal–ligand complexes are applied in asymmetric hydrogenation, allylic substitution, hydroformylation, and cross-coupling reactions, which are critical in the synthesis of enantiomerically pure pharmaceuticals, fine chemicals, and agrochemicals. The compound is also used in research for developing new chiral catalysts, studying reaction mechanisms, and optimizing catalytic efficiency and selectivity. Its ferrocene scaffold imparts rigidity and stability to the ligand, enhancing performance under demanding reaction conditions.

The compound offers multiple advantages due to its rigid ferrocene backbone, chiral environment, and versatile coordination ability. The stereochemically defined dimethylaminoethyl group provides excellent enantioselectivity, while the diphenylphosphino moiety ensures strong and stable coordination to transition metals. The ferrocene core contributes thermal and chemical stability, maintaining catalyst performance even under harsh conditions. Its tunable electronic and steric properties allow fine control over reaction outcomes, including yield, selectivity, and stereochemistry. The ligand is soluble in common organic solvents and can be efficiently incorporated into various metal complexes, providing reproducible and high-performance results for both laboratory-scale and industrial asymmetric synthesis.