Hangzhou Leap Chem Co., Ltd. is one of the most professional manufacturers and suppliers of sulfathiazole sodium丨cas 144-74-1 in China. Welcome to wholesale bulk high quality chemical products at competitive price from our factory. If you have any enquiry about custom service, please feel free to email us.
Specifications of Sulfathiazole sodium丨144-74-1
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Property |
Specification |
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Description |
White to yellowish crystalline grain or powder |
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Purity (HPLC) |
99% min |
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Identification A (IR spectrometry) |
Should correspond to the spectrum of a standard sulfathiazole sample in the range from 2000 cm-1 to 400 cm-1 |
|
Identification B (Qualitative reaction) |
Gives a characteristic reaction to primary aromatic amines |
|
Identification C (Qualitative reaction) |
Gives a characteristic reaction B to sodium |
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Loss on drying |
6~9% |
|
Water solubility (25°C) |
5g/10mL min |
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Solution transparency |
5% aqueous solution of the drug should be transparent |
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pH (1% water solution) |
9.0~10.0 |
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Sulfonamide |
0.5% max |
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Amount of impurities |
2% max |
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Particle size |
Should pass 20 mesh sieve (≤1mm) |
Transport Information of Sulfathiazole sodium丨144-74-1
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Parameter |
Specification |
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UN Number |
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Class |
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Packing Group |
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H.S. Code |
2935900090101 |
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Stability & Reactivity |
Stable |
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Storage |
Tightly closed. Store in a closed, dry, ventilated place |
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Condition to Avoid |
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Package |
Manufacturing Information of Sulfathiazole sodium丨144-74-1
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Parameter |
Specification |
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Capacity |
10MT/month |
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Frequency |
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Main Export Countries |
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Capacity/Batch |
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Experience |
Production since 2008, MOQ 500kg for custom orders |
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Facilities |
Introduction
Sulfathiazole sodium丨144-74-1 is a sulfonamide antibiotic used in the treatment of bacterial infections. It is a sodium salt of sulfathiazole, which is itself a member of the sulfonamide class of drugs. Sulfonamides were among the first synthetic antibiotics and continue to be used in various medical and veterinary applications.
Mechanism of Action
Sulfathiazole sodium works by inhibiting the synthesis of folic acid in bacteria. Folic acid is essential for the synthesis of nucleotides, which are needed for DNA replication and cell division. By blocking the enzyme dihydropteroate synthase, which is involved in the production of folic acid, sulfathiazole prevents bacteria from growing and reproducing.
Since human cells do not rely on this pathway (they obtain folic acid from their diet), the drug selectively targets bacteria, making it effective against bacterial infections with minimal harm to the host.
Uses of Sulfathiazole sodium丨144-74-1
Antibacterial Treatment
Infections: Sulfathiazole sodium is primarily used for the treatment of various bacterial infections, particularly those caused by Gram-positive organisms such as Streptococcus and Staphylococcus, as well as certain Gram-negative bacteria. It is commonly used to treat respiratory tract infections, urinary tract infections (UTIs), and wound infections.
Combination Therapy: It can also be used in combination with other antibiotics or chemotherapeutic agents to treat infections, particularly in cases of broad-spectrum bacterial infections.
Veterinary Medicine
Livestock and Pets: Sulfathiazole sodium丨144-74-1 is used in veterinary medicine to treat bacterial infections in livestock and pets. It is particularly effective in the treatment of infections in cattle, poultry, and dogs, where it is used to manage diseases such as pneumonia, enteritis, and skin infections.
Topical Application
Wound Care: In some cases, sulfathiazole sodium is used in topical formulations for treating skin infections or wounds. It helps prevent and control bacterial growth on the skin, particularly for burns and skin ulcers.
Preventive Use in Surgery
Prophylactic Use: Sulfathiazole sodium may be used as a prophylactic antibiotic to prevent infections following surgical procedures, particularly when there is a high risk of bacterial contamination.
Benefits of Sulfathiazole sodium丨144-74-1
Broad-Spectrum Activity:
Sulfathiazole sodium is effective against a wide variety of bacteria, making it useful in treating infections caused by both Gram-positive and Gram-negative pathogens. This broad-spectrum activity helps in treating infections where the causative bacteria may not be immediately known.
Cost-Effective:
Compared to many newer antibiotics, sulfathiazole sodium is relatively inexpensive, making it an affordable option in both human and veterinary medicine. This can be particularly important in resource-limited settings where access to newer antibiotics might be restricted.
Topical Use:
The drug's use in topical applications makes it useful in treating localized skin infections and wounds, where systemic antibiotics may not be necessary or desirable. It helps reduce the risk of wound infection and promotes healing.
Established Safety Profile:
Sulfathiazole sodium has been used for many decades and has an established safety profile when used appropriately. The drug has a history of low toxicity compared to some other antibiotics, particularly when used topically or in lower doses for infections.
Conclusion
Sulfathiazole sodium丨144-74-1 is a sulfonamide antibiotic with broad-spectrum activity against a wide range of bacterial infections. It is used in both human and veterinary medicine to treat infections of the respiratory tract, urinary tract, and skin. Its topical and systemic applications make it a versatile option for infection control. Despite its benefits, the drug is associated with the potential for allergic reactions, gastrointestinal issues, and blood-related side effects. Resistance to the drug may develop over time, limiting its long-term efficacy. Proper use, appropriate dosing, and monitoring of side effects are essential to maximizing its benefits and minimizing risks.
