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Specifications of Arbidol hydrochloride丨131707-23-8
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Property |
Specification |
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Appearance |
From white to white with a greenish-yellowish or brownish shade crystalline powder |
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Solubility |
Sparingly soluble or slightly soluble in chloroform and ethanol 96%, practically insoluble in water |
|
Identification |
IR spectrum corresponds to the applied IR spectrum UV spectrum: Absorption at (225 ±2) nm, (255 ± 2) nm, and (316 ± 2) nm, with min. absorption at (244 ±2) nm and (284 ±2) nm Qualitative reaction of Chlorides and bromides |
|
Related Impurities |
Not more than 0.5% |
|
Sulphated Ash |
Not more than 0.1% |
|
Heavy Metals |
Not more than 0.001% |
|
Water Content |
From 3.0 to 4.0% |
|
Residual Solvents |
Acetone: Not more than 0.5% Ethanol: Not more than 0.5% |
|
Assay |
From 99.0% to 101.0% |
Transport Information of Arbidol hydrochloride丨131707-23-8
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Parameter |
Specification |
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UN Number |
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Class |
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Packing Group |
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H.S. Code |
2932999099117 |
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Stability & Reactivity |
Stable |
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Storage |
Tightly closed. Store in a closed, dry, ventilated place |
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Condition to Avoid |
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|
Package |
25kg/drum |
Manufacturing Information of Arbidol hydrochloride丨131707-23-8
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Parameter |
Specification |
|
Capacity |
6MT/month |
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Frequency |
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Main Export Countries |
Russia, EU |
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Capacity/Batch |
500kg/batch |
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Experience |
Production since 2012, MOQ 500kg |
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Facilities |
Introduction
Arbidol hydrochloride, with the Chemical Abstracts Service (CAS) number 131707-23-8, is an antiviral drug with the chemical name ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-1H-indole-3-carboxylate hydrochloride. It is a broad-spectrum antiviral agent primarily used for the prevention and treatment of influenza and other respiratory viral infections. Arbidol hydrochloride has gained attention for its potential activity against a range of viruses, including coronaviruses.
Applications of Arbidol hydrochloride丨131707-23-8
1. Influenza Treatment and Prevention:
- Arbidol hydrochloride is widely used in countries like Russia and China for the treatment and prophylaxis of influenza A and B viruses. It works by inhibiting viral fusion with host cell membranes, preventing viral entry and replication.
2. Respiratory Viral Infections:
- It has shown efficacy against other respiratory viruses, such as respiratory syncytial virus (RSV) and adenoviruses, making it a versatile antiviral agent.
3. Coronavirus Infections:
- Arbidol hydrochloride has been studied for its potential activity against coronaviruses, including SARS-CoV-2 (the virus responsible for COVID-19). It has been used in some countries as part of combination therapy for COVID-19, though its efficacy remains under investigation.
4. Immunomodulatory Effects:
- In addition to its antiviral properties, Arbidol hydrochloride has been reported to modulate the immune system, enhancing the body's antiviral response.
5. Research and Development:
- Arbidol hydrochloride丨131707-23-8 is used in antiviral research to study its mechanisms of action and potential applications against emerging viral pathogens.
Benefits of Arbidol hydrochloride丨131707-23-8
1. Broad-Spectrum Antiviral Activity:
- Its ability to target multiple viruses, including influenza and coronaviruses, makes it a valuable tool in combating respiratory viral infections.
2. Prophylactic Use:
- Arbidol hydrochloride can be used to prevent viral infections, particularly during outbreaks or seasonal influenza epidemics.
3. Low Resistance Development:
- Compared to other antiviral drugs, Arbidol hydrochloride has a lower likelihood of inducing viral resistance, making it a reliable option for long-term use.
4. Immunomodulatory Properties:
- Its ability to enhance immune responses may provide additional benefits in fighting viral infections.
5. Clinical Use:
- Arbidol hydrochloride丨131707-23-8 has been used clinically for decades in certain countries, with a well-established safety profile when used as directed.
Safety and Considerations
1. Side Effects:
- Common side effects of Arbidol hydrochloride include gastrointestinal discomfort, dizziness, and allergic reactions. These are generally mild and resolve on their own.
2. Regulatory Status:
- Arbidol hydrochloride is approved for use in Russia, China, and some other countries, but it is not widely approved in Western countries. Its use for COVID-19 remains off-label and subject to further clinical trials.
3. Drug Interactions:
- As with any medication, Arbidol hydrochloride may interact with other drugs. Patients should consult healthcare providers before use.
4. Pregnancy and Lactation:
- The safety of Arbidol hydrochloride during pregnancy and breastfeeding has not been fully established. It should be used only if the potential benefits outweigh the risks.
Conclusion
Arbidol hydrochloride丨131707-23-8 is a broad-spectrum antiviral drug with applications in the treatment and prevention of influenza, respiratory viral infections, and potentially coronaviruses. Its ability to inhibit viral fusion and modulate the immune system makes it a valuable tool in antiviral therapy. While its safety profile is generally favorable, further research is needed to fully establish its efficacy, particularly against emerging viruses like SARS-CoV-2. As antiviral resistance and new viral threats continue to challenge global health, Arbidol hydrochloride remains a promising candidate for future therapeutic development.
