N-Methyl-2-fluoro-4-aminobenzamide丨CAS 915087-25-1

N-Methyl-2-fluoro-4-aminobenzamide (CAS 915087-25-1) is an important organic intermediate used primarily in pharmaceutical and medicinal chemistry research. Its functional groups-a fluoro-substituted aromatic ring, an amide, and a methylated amino group-make it highly versatile for the synthesis of biologically active compounds, including enzyme inhibitors, receptor modulators, and small-molecule drug candidates. It is commonly employed in the preparation of substituted benzamide derivatives, heterocyclic compounds, and fluorinated analogs in structure–activity relationship (SAR) studies. Additionally, it serves as a building block in the development of radiolabeled compounds and other specialized intermediates for pharmaceutical R&D and high-throughput screening applications.

The benefits of N-Methyl-2-fluoro-4-aminobenzamide stem from its chemical stability, defined stereochemistry, and multifunctional reactivity. The fluorine atom enhances metabolic stability and modulates electronic properties, which is valuable in drug design and medicinal chemistry. The amide and amino functionalities allow selective derivatization and incorporation into larger molecular frameworks under standard synthetic conditions. Its high purity, solubility in organic solvents, and compatibility with common coupling reactions make it reliable for reproducible synthesis and downstream functionalization. These characteristics enable efficient preparation of target compounds with predictable properties and optimized biological activity.