N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide丨CAS 356068-86-5

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide (CAS 356068-86-5) is a functionalized pyrrole derivative primarily used as an intermediate in pharmaceutical and medicinal chemistry. Its structure, featuring a pyrrole core, aldehyde functionality, and diethylaminoethyl side chain, makes it suitable for the synthesis of bioactive molecules, including enzyme inhibitors, receptor ligands, and therapeutic candidates. It is particularly valuable in drug discovery for designing compounds with targeted biological activity, including central nervous system agents and anticancer therapeutics. The aldehyde and carboxamide groups provide reactive sites for condensation, coupling, and derivatization reactions, allowing the creation of structurally diverse analogues for structure–activity relationship (SAR) studies.

The benefits of this pyrrole derivative lie in its multifunctional reactivity and structural versatility. The aldehyde group enables selective condensation and Schiff base formation, while the diethylaminoethyl moiety improves solubility and can enhance pharmacokinetic properties of derivatives. The pyrrole ring provides a rigid, planar scaffold that supports binding interactions in biological targets, and the carboxamide group allows further functionalization or hydrogen-bond interactions. This combination of features makes the compound a highly adaptable intermediate for medicinal chemistry, enabling the design of molecules with improved potency, selectivity, and drug-like properties.