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Specifications of Estramustine phosphate sodium丨CAS 52205-73-9
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Appearance: |
white to off white powder |
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Purity: |
97.0% min |
Overview
Estramustine phosphate sodium丨CAS 52205-73-9 is a chemotherapeutic agent specifically designed to target hormone-sensitive cancers. It combines the hormonal action of estrogen with the cytotoxic effect of alkylating agents, offering a dual mechanism of action.
Applications of Estramustine phosphate sodium丨CAS 52205-73-9
1. Treatment of Prostate Cancer
● Primary Use: Estramustine phosphate sodium丨CAS 52205-73-9 is primarily used in the palliative treatment of metastatic or advanced prostate cancer, especially hormone-refractory or castration-resistant prostate cancer.
● Mechanism: It disrupts microtubule function and mitotic spindle formation, leading to inhibition of cell division and tumor cell apoptosis.
● Hormonal Influence: The estradiol moiety provides a degree of androgen suppression, which is beneficial in prostate cancer where growth is often driven by androgens.
2. Cytostatic Agent in Oncology
● Antimitotic Action: Estramustine interferes with microtubule dynamics in rapidly dividing cells, thus functioning as a microtubule-targeting agent. Unlike traditional nitrogen mustards, its cytotoxicity is more focused on mitotic inhibition than DNA alkylation.
● Combination Therapy: Often used in combination with other anticancer agents such as docetaxel or vinblastine to enhance efficacy and manage resistance.
3. Research Applications
● Cancer Biology Studies: Used in preclinical research and in vitro models to investigate:
oMicrotubule-associated protein functions
oHormone-responsive tumor growth
oThe interplay between hormonal therapy and chemotherapy
● Drug Resistance Mechanism Studies: Serves as a model compound in studying resistance mechanisms in hormone-sensitive malignancies.
Benefits of Estramustine phosphate sodium丨CAS 52205-73-9
1. Dual Mechanism of Action
● Combines the estrogenic suppression of prostate cell growth with microtubule inhibition, making it unique among chemotherapeutics.
● Reduces the need for separate hormonal and cytotoxic agents.
2. Selective Targeting of Prostate Cancer Cells
● Estramustine preferentially accumulates in prostate tissue and prostatic tumors, leading to site-specific activity and minimizing off-target toxicity compared to non-selective cytotoxins.
3. Oral Administration
● Can be administered orally, offering patient convenience and reducing the need for intravenous infusions, which is especially beneficial in palliative care settings.
4. Synergistic in Combination Therapy
● Shows synergistic effects when used with other chemotherapeutics like taxanes and platinum-based drugs, often improving progression-free survival in advanced-stage patients.
Conclusion
Estramustine phosphate sodium丨CAS 52205-73-9 is a specialized cytostatic agent used mainly in the treatment of advanced prostate cancer. Its unique design-merging an estrogen component with an alkylating agent-offers dual anti-tumor effects, making it effective especially in hormone-resistant cases. With benefits like site-specific targeting, oral availability, and microtubule disruption, estramustine phosphate sodium remains a valuable tool in the oncologist's arsenal and a compound of interest in cancer research.
