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Major Supplier of Erdafitinib丨CAS 1346242-81-6
Erdafitinib, also known as JNJ-42756493, is an orally bioavailable, small-molecule tyrosine kinase inhibitor belonging to the fibroblast growth factor receptor (FGFR) inhibitor class. It contains a quinoxaline core, a methylpyrazole group, and a dimethoxyphenyl substituent. By inhibiting FGFR1, FGFR2, FGFR3, and FGFR4 signaling, it is an important targeted anticancer compound used in pharmaceutical development and oncology research.
Chemical Identifiers
| InChI | 1S/C25H30N6O2/c1-17(2)26-8-9-31(20-10-21(32-4)13-22(11-20)33-5)19-6-7-23-24(12-19)29-25(15-27-23)18-14-28-30(3)16-18/h6-7,10-17,26H,8-9H2,1-5H3 |
| InChI Key | OLAHOMJCDNXHFI-UHFFFAOYSA-N |
| Smiles | CC(C)NCCN(C1=CC2=NC(=CN=C2C=C1)C3=CN(N=C3)C)C4=CC(=CC(=C4)OC)OC |
| EC No. |
807-395-6 |
| MDL No. | MFCD28502040 |
| PubChem CID | 67462786 |
Applications
Targeted Cancer Therapy
Used as an active pharmaceutical ingredient in the treatment of locally advanced or metastatic urothelial carcinoma in patients with susceptible FGFR2 or FGFR3 genetic alterations, according to approved prescribing indications.
FGFR Signaling Research
Serves as a selective inhibitor for investigating FGFR1–4 activity and their roles in cell growth, differentiation, and intracellular signaling pathways.
Anticancer Drug Discovery
Used in preclinical studies to evaluate the effects of FGFR inhibition on tumor-cell proliferation, survival, and tumor growth in cellular and animal models.
Biomarker-Guided Oncology Research
Supports research into FGFR genetic alterations, including mutations, amplifications, and gene fusions, helping investigate the relationship between molecular biomarkers and responses to targeted therapies.
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