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Specifications
| Appearance: | White powder |
| Identification (HPLC): | The retention time of the principal peak in the test solution HPLC chromatogram obtained under conditions described in section Related Substances corresponds to the retention time of the principal peak in the standard solution |
| Melting Point: | 197℃ - 202℃ |
| Loss on Drying: | 1.0% max |
| Sulphated Ash: | 0.20% max |
| Related Substance (HPLC): | Purity: 95% min Single highest impurity: 2.0% max Total impurities: 5.0% max |
| Assay (by titration, dry): | 98.0% - 101.0% |
Applications
Cholic acid is a primary bile acid widely used in pharmaceutical, biochemical, and chemical research. In medicine, it serves as a therapeutic agent for certain liver and gallbladder disorders, aiding in the digestion and absorption of fats by facilitating bile acid circulation. It is also employed as a precursor in the synthesis of steroidal drugs, bile acid derivatives, and conjugates for pharmaceutical applications. In biochemical research, cholic acid is used to study lipid metabolism, bile acid transport, and as a solubilizing agent for hydrophobic compounds in enzymatic and cellular assays. Additionally, it finds applications in cosmetic formulations for skin and hair care due to its emulsifying and cleansing properties.
Benefits
Cholic acid offers several advantages due to its amphipathic structure and biological compatibility. Its hydrophilic and hydrophobic regions allow it to act as an effective emulsifier, improving solubility of lipophilic substances in aqueous systems. The compound is biologically active, supporting natural lipid digestion and absorption, and serves as a safe precursor for synthetic bile acids and steroidal drugs. It is chemically stable under normal storage conditions and compatible with a wide range of synthetic transformations, making it useful in both laboratory research and industrial applications. Cholic acid also contributes to the development of drug delivery systems by enhancing solubilization and bioavailability of poorly soluble compounds.
Conclusion
Cholic acid is a versatile bile acid with broad applications in pharmaceuticals, biochemical research, and cosmetics. Its amphipathic structure, biological activity, and chemical stability make it valuable for drug synthesis, lipid metabolism studies, and solubilization of hydrophobic compounds. The compound continues to be an essential tool for medical, research, and industrial applications involving bile acids and steroidal derivatives.
