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Specifications of 4-Hydroxyindole丨CAS 2380-94-1
|
Appearance |
Light grey, greenish-grey or greenish-brown powder |
|
Assay (HPLC) |
98.5% min |
|
Melting point |
95–100 °C |
|
Loss on drying |
0.5% max |
|
Sum of impurities (GC) |
1.0% max |
Applications
1. Pharmaceutical and Medicinal Chemistry
Intermediate in drug synthesis:
Serves as a building block in the synthesis of bioactive compounds, especially those with serotonin-related activity.
Lead structure for CNS drugs:
The indole ring is a privileged scaffold in neuropharmacology; 4-hydroxyindole is used to explore analogs for antidepressant, anxiolytic, or antipsychotic agents.
2. Neurochemical Research
Metabolite mimic:
Structurally similar to serotonin and melatonin analogs, making it valuable in the study of neurotransmitter pathways.
Useful for developing radiolabeled tracers or fluorescent probes for indole-containing biomolecules.
3. Chemical and Biochemical Research
Synthetic precursor:
Used in organic synthesis for the preparation of indole-based ligands, catalysts, and functional materials.
4-Hydroxyindole丨CAS 2380-94-1 plays a role in the development of bioinspired materials or heterocyclic libraries for screening.
4. Pigment and Dye Chemistry
Can be used as a starting material for the development of functional dyes and colorants, particularly those mimicking natural indole-derived pigments.
Benefits
✅ 1. Versatile Synthetic Intermediate
The hydroxyl group at the 4-position provides a handle for functionalization through etherification, acylation, or oxidation, enabling the construction of a wide range of derivatives.
✅ 2. Biocompatible Scaffold
As a derivative of indole, which is naturally found in tryptophan, serotonin, and melatonin, 4-hydroxyindole offers biocompatibility and pharmacological relevance.
✅ 3. Electron-Rich Aromatic System
The molecule's electron-donating hydroxyl group enhances reactivity, making it useful in electrophilic aromatic substitution reactions and coupling chemistry.
✅ 4. Research Tool for Neuroscience and Biochemistry
Enables the study of indole metabolism, receptor binding, and enzyme activity in brain and endocrine systems.
Summary
4-Hydroxyindole丨CAS 2380-94-1 is a valuable compound in chemical synthesis, pharmaceutical R&D, and neurochemical research, owing to its structural similarity to bioactive indoles and its functional versatility. Its applications range from drug discovery and metabolite studies to the design of pigments and dyes, making it an important tool in both academic and industrial laboratories.
