Anthranilonitrile丨CAS 1885-29-6

Anthranilonitrile is an important aromatic nitrile intermediate widely used in pharmaceutical research, agrochemical synthesis, and fine chemical production. It serves as a key building block in the preparation of heterocyclic compounds, including quinazolines, quinazolinones, benzodiazepines, and other nitrogen-containing ring systems. In medicinal chemistry, anthranilonitrile is applied in the synthesis of drug candidates with anticancer, antimicrobial, anti-inflammatory, and central nervous system activities. In agrochemical development, it is used to produce herbicides, insecticides, and fungicides with enhanced biological efficacy. The compound is also employed in dye and pigment manufacturing, photographic chemicals, and specialty polymer additives. In organic synthesis, it functions as a versatile precursor for amides, acids, amidines, and heterocycles through hydrolysis, cyclization, and substitution reactions.

The benefits of anthranilonitrile arise from its dual functional groups, high reactivity, and synthetic flexibility. The presence of both amino and nitrile groups enables diverse chemical transformations, allowing access to a wide range of derivatives and heterocyclic frameworks. Its ortho-substitution pattern facilitates intramolecular cyclization reactions, supporting efficient construction of fused and condensed ring systems. Anthranilonitrile exhibits good stability under standard storage conditions and compatibility with common organic solvents and reagents. Its well-defined structure and consistent purity support reproducible reaction outcomes in laboratory and industrial synthesis. Additionally, it allows multi-step functionalization, making it valuable for structure–activity relationship studies and process optimization.