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Specifications of 5-(Ethylthio)-1H-tetrazole丨CAS 89797-68-2
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Appearance: |
White to off-white crystalline powder |
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Purity (HPLC): |
99.0% min |
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Assay (Titration): |
98.0% - 101.0% |
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Particulates: |
No visible particulates |
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Melting point: |
85.0°C to 89.0°C |
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Solubility (1 mol/L, CH₃CN, 25°C): |
Clear and colorless |
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Water (KF): |
0.030% max |
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Conductivity (0.35M, CH₃CN): |
0.00 - 200.00 μS/cm |
Transport Information of 5-(Ethylthio)-1H-tetrazole丨CAS 89797-68-2
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Parameter |
Specification |
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UN Number |
2925 |
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Class |
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Packing Group |
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H.S. Code |
2933990099 |
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Stability & Reactivity |
The product is chemically stable under standard ambient conditions. |
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Storage |
Store in original container. Tightly closed and away from sources of ignition and heat. Observe national regulations. Recommended storage temperature 2 - 8 °C |
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Condition to Avoid |
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Package |
Overview
5-(Ethylthio)-1H-tetrazole丨CAS 89797-68-2 is a heterocyclic compound notable for its tetrazole core, which is a nitrogen-rich five-membered ring, and an alkylthio substituent. This structure imparts unique chemical properties such as acidity, coordination ability, and participation in various synthetic pathways.
Applications
1. Pharmaceutical Intermediates
5-(Ethylthio)-1H-tetrazole丨CAS 89797-68-2 is widely used as an intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly in drugs containing tetrazole rings.
The tetrazole moiety is a common bioisostere for carboxylic acid groups, improving metabolic stability and bioavailability of drugs.
Often used in the synthesis of angiotensin II receptor antagonists (ARBs), such as losartan and related antihypertensive agents.
2. Agrochemical Synthesis
Utilized in the preparation of pesticides and herbicides that contain tetrazole functionalities, contributing to enhanced efficacy and environmental stability.
3. Coordination Chemistry
The tetrazole ring and ethylthio group can act as ligands for metal coordination complexes, useful in catalysis or materials science research.
4. Organic Synthesis
Acts as a building block for heterocyclic chemistry, facilitating the synthesis of novel compounds with potential pharmaceutical or material applications.
Benefits
1. Chemical Stability and Versatility
The tetrazole ring offers high nitrogen content and aromaticity, lending chemical stability and unique reactivity.
The ethylthio substituent increases lipophilicity and can modulate the biological activity and solubility of derivatives.
2. Improved Drug Properties
As a tetrazole derivative, it allows synthesis of drugs with improved pharmacokinetics compared to carboxylic acid analogs.
3. Synthetic Utility
Provides a versatile platform for further chemical modifications, enabling the creation of diverse functional molecules.
Conclusion
5-(Ethylthio)-1H-tetrazole丨CAS 89797-68-2 is an important chemical intermediate widely used in the pharmaceutical and agrochemical industries. Its unique tetrazole ring combined with an ethylthio group confers valuable chemical and biological properties, supporting the synthesis of bioactive compounds with enhanced stability and efficacy. Proper handling ensures safe use in research and industrial applications.
