Hangzhou Leap Chem Co., Ltd. is one of the most professional manufacturers and suppliers of 5-bromo-2,2-difluorobenzodioxole丨cas 33070-32-5 in China. Welcome to wholesale bulk high quality chemical products at competitive price from our factory. If you have any enquiry about custom service, please feel free to email us.
Specifications
| Appearance | colorless to pale yellow liquid |
| Purity | 98% min |
| Water | 0.5% max |
Applications
Pharmaceutical Intermediate: Serves as a versatile building block for synthesizing drug candidates that require a difluoromethylene-dioxole moiety combined with an aromatic bromine substitution.
Agrochemical Development: Used in the synthesis of active ingredients for crop protection products, where the dioxole ring can enhance metabolic stability.
Advanced Material Synthesis: Incorporated into specialty chemicals, dyes, and pigments to improve thermal and photochemical stability.
Coupling Reactions: The bromine substituent allows for further functionalization via palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Heck), enabling diverse structural modifications.
Benefits
Dual Functional Sites: The presence of both the bromine atom and the difluorodioxole ring provides multiple reactive handles for complex molecule construction.
Enhanced Stability: The dioxole ring contributes to chemical and thermal stability, making derivatives more robust during processing.
Versatile Reactivity: Compatible with a range of coupling and substitution reactions, allowing chemists to design a wide variety of derivatives.
Compact Molecular Design: Introduces electron-withdrawing fluorine atoms that can modulate biological activity and improve pharmacokinetic profiles in drug candidates.
Conclusion
5-Bromo-2,2-difluorobenzodioxole is a valuable multifunctional intermediate used across pharmaceuticals, agrochemicals, and advanced material synthesis. Its unique structure, combining a brominated aromatic system with a difluorodioxole moiety, provides both reactivity and stability. This dual functionality enables the efficient creation of complex, high-value molecules with tailored properties.
