(3S)-3-Amino-1-butanol丨CAS 61477-39-2

1. Pharmaceutical Intermediate
(3S)-3-Amino-1-butanol丨CAS 61477-39-2 is widely used as a chiral building block in the synthesis of active pharmaceutical ingredients (APIs). Its stereochemistry makes it particularly valuable for:
● Antiretroviral drugs: Notably used in the synthesis of Dolutegravir, an HIV integrase inhibitor.
● Chiral amines and amino alcohols: Serves as a precursor in synthesizing compounds with biological activity.
● β-Amino alcohol derivatives: Important in the development of β-blockers, neuroactive compounds, and enzyme inhibitors.

2. Asymmetric Synthesis & Chiral Ligands
Due to its chiral center, (3S)-3-amino-1-butanol is useful in:
● Chiral catalyst design for enantioselective reactions
● Asymmetric synthesis of optically pure compounds in medicinal chemistry
● Serving as a ligand or auxiliary in stereoselective transformations

3. Fine Chemicals and Agrochemical Industry
● Used in the synthesis of specialty chemicals and bioactive intermediates
● May be incorporated into chiral agrochemicals requiring specific stereochemistry for efficacy

4. Research and Development
In chemical biology and drug discovery labs, this compound is:
● Employed as a model compound for understanding amino alcohol reactivity
● Used in the development of novel peptidomimetics, hybrid molecules, and other biologically active analogs

√ Chiral Purity
The (3S)-enantiomer ensures stereoselective advantages in drug synthesis, enhancing pharmacological activity and reducing side effects.
√ Versatility
Both the hydroxyl and amino functional groups provide multiple handles for chemical transformations, improving synthetic flexibility.
√ High Reactivity
Its small molecular size and functional groups allow for easy derivatization and functional incorporation into larger molecular frameworks.
√ Industrial Scalability
Commercially available in bulk, making it suitable for large-scale pharmaceutical manufacturing.

Conclusion
(3S)-3-Amino-1-butanol丨CAS 61477-39-2 is a high-value chiral amino alcohol with extensive applications in pharmaceutical synthesis, particularly as a key intermediate in antiviral agents like Dolutegravir. Its combination of reactivity, stereochemical purity, and versatility make it a crucial component in both industrial and research-based synthetic chemistry. As demand for chiral drug synthesis grows, this compound remains an essential tool for modern drug development.