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Specifications
|
Appearance |
Off-white crystalline powder |
|
Purity (HPLC) |
99% min |
|
Water |
0.5% max |
Applications of 2-Thiouracil丨CAS 141-90-2
1. Pharmaceuticals and Endocrinology
● Antithyroid Agent:
Historically used in the treatment of hyperthyroidism and Graves' disease, 2-thiouracil acts by inhibiting the synthesis of thyroid hormones.
o It blocks thyroid peroxidase, an enzyme necessary for iodination of tyrosine residues in thyroglobulin, thus preventing thyroxine (T₄) and triiodothyronine (T₃) production.
o Though now largely replaced by safer alternatives (like methimazole or propylthiouracil), it still holds historical and research significance.
2. Biochemical Research
● Model compound for studying nucleobase modifications:
Used in structural and mechanistic studies involving RNA and DNA, particularly for examining the effects of sulfur substitution on hydrogen bonding and base pairing.
● Studied in enzyme inhibition assays and metabolic pathway analyses involving pyrimidine analogs.
3. Agricultural and Veterinary Studies
● Investigated as a potential growth regulator and thyroid function modulator in animals, especially in research settings.
● Occasionally explored in toxicological assessments of environmental or dietary exposure to thiouracil derivatives.
4. Intermediate in Organic Synthesis
● Used as a precursor or reagent in the synthesis of other heterocyclic compounds, pharmaceuticals, and pyrimidine-based drugs.
Benefits
1. Biological Activity
● 2-Thiouracil丨CAS 141-90-2 acts as a potent inhibitor of thyroid hormone biosynthesis, offering a mechanism of action useful in both clinical pharmacology and endocrinological research.
2. Structural Versatility
● Its chemical structure allows for various modifications and derivatizations, making it a useful building block in medicinal chemistry and nucleic acid analog synthesis.
3. Tool for Molecular Studies
● Valuable in the study of sulfur-substituted nucleobases, which helps improve understanding of base-pairing, RNA stability, and tRNA modifications.
Conclusion
2-Thiouracil丨CAS 141-90-2 is a sulfur-containing uracil derivative known for its antithyroid properties, historically used in the management of hyperthyroidism. Though largely replaced in clinical use, it remains relevant in biomedical research, especially for its role in nucleobase studies, enzyme inhibition, and organic synthesis. With a well-characterized biological mechanism and structural versatility, 2-thiouracil continues to serve as an important scientific and chemical tool in academic and pharmaceutical laboratories.
